In utero and postnatal exposure to Environmental Tobacco Smoke (ETS) alters alveolar and Respiratory Bronchiole (RB) growth and development in infant monkeys

Mark V Avdalovic, Lei Putney, Nancy Tyler, Walter Finkbeiner, Kent E Pinkerton, Dallas Hyde

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The direct effect of environmental tobacco smoke (ETS) exposure in utero on the development of the lung parenchyma is not known. We used design-based stereologic methods to evaluate in utero and postnatal ETS exposure on alveolar and respiratory bronchiole (RB) development in the rhesus macaque. METHODS Timed-pregnant rhesus macaques and their offspring were exposed to filtered air or various amounts of ETS during the prenatal and postnatal period. The left cranial lobe from necropsied infants was evaluated by design-based stereological methods and general pathological review. RESULTS Infants in the in utero and six-month ETS groups had an 18% and 17% relative decrease, respectively, in alveolar number and a 57% and 33% increase, respectively, in alveolar size compared to filtered air (FA) monkeys. Lung volume positively correlated with alveolar number in the FA and six-month ETS group and negatively correlated in the in utero ETS group. The distribution of alveolar size was much more variable in the in utero group. Overall, RB volume was significantly increased in the six-month ETS group (p < .04). CONCLUSIONS Taken together, these results indicate that in utero and postnatal ETS exposure is associated with altered parenchymal lung development.

Original languageEnglish (US)
Pages (from-to)256-263
Number of pages8
JournalToxicologic Pathology
Volume37
Issue number2
DOIs
StatePublished - Feb 2009

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Bronchioles
Tobacco
Environmental Exposure
Growth and Development
Smoke
Haplorhini
Air
Macaca mulatta
Lung

Keywords

  • Developmental pathology
  • Inhalation
  • Lung
  • Morphometry
  • Nonhuman primate pathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology
  • Molecular Biology

Cite this

In utero and postnatal exposure to Environmental Tobacco Smoke (ETS) alters alveolar and Respiratory Bronchiole (RB) growth and development in infant monkeys. / Avdalovic, Mark V; Putney, Lei; Tyler, Nancy; Finkbeiner, Walter; Pinkerton, Kent E; Hyde, Dallas.

In: Toxicologic Pathology, Vol. 37, No. 2, 02.2009, p. 256-263.

Research output: Contribution to journalArticle

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abstract = "The direct effect of environmental tobacco smoke (ETS) exposure in utero on the development of the lung parenchyma is not known. We used design-based stereologic methods to evaluate in utero and postnatal ETS exposure on alveolar and respiratory bronchiole (RB) development in the rhesus macaque. METHODS Timed-pregnant rhesus macaques and their offspring were exposed to filtered air or various amounts of ETS during the prenatal and postnatal period. The left cranial lobe from necropsied infants was evaluated by design-based stereological methods and general pathological review. RESULTS Infants in the in utero and six-month ETS groups had an 18{\%} and 17{\%} relative decrease, respectively, in alveolar number and a 57{\%} and 33{\%} increase, respectively, in alveolar size compared to filtered air (FA) monkeys. Lung volume positively correlated with alveolar number in the FA and six-month ETS group and negatively correlated in the in utero ETS group. The distribution of alveolar size was much more variable in the in utero group. Overall, RB volume was significantly increased in the six-month ETS group (p < .04). CONCLUSIONS Taken together, these results indicate that in utero and postnatal ETS exposure is associated with altered parenchymal lung development.",
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