Abstract
Nitric oxide (NO) mediates a vast array of physiological functions in the lungs, and our understanding of these events has improved dramatically over the past decade. Once produced enzymatically and intracellularly, NO can diffuse as a free molecule, or undergo chemical reactions to preserve and alter the biological activity. In silico modeling of these non-linear, multiscale and dynamic processes plays a crucial role in our understanding of, and thus our ability to manipulate, these events to treat pulmonary disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 147-153 |
| Number of pages | 7 |
| Journal | Drug Discovery Today: Disease Models |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2007 |
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ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
Cite this
In silico modeling of nitric oxide production, transport and consumption in the lungs. / Shelley, David A.; Shin, Hye Won; George, Steven.
In: Drug Discovery Today: Disease Models, Vol. 4, No. 3, 01.09.2007, p. 147-153.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - In silico modeling of nitric oxide production, transport and consumption in the lungs
AU - Shelley, David A.
AU - Shin, Hye Won
AU - George, Steven
PY - 2007/9/1
Y1 - 2007/9/1
N2 - Nitric oxide (NO) mediates a vast array of physiological functions in the lungs, and our understanding of these events has improved dramatically over the past decade. Once produced enzymatically and intracellularly, NO can diffuse as a free molecule, or undergo chemical reactions to preserve and alter the biological activity. In silico modeling of these non-linear, multiscale and dynamic processes plays a crucial role in our understanding of, and thus our ability to manipulate, these events to treat pulmonary disease.
AB - Nitric oxide (NO) mediates a vast array of physiological functions in the lungs, and our understanding of these events has improved dramatically over the past decade. Once produced enzymatically and intracellularly, NO can diffuse as a free molecule, or undergo chemical reactions to preserve and alter the biological activity. In silico modeling of these non-linear, multiscale and dynamic processes plays a crucial role in our understanding of, and thus our ability to manipulate, these events to treat pulmonary disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=42049110777&partnerID=8YFLogxK
U2 - 10.1016/j.ddmod.2007.06.006
DO - 10.1016/j.ddmod.2007.06.006
M3 - Review article
AN - SCOPUS:42049110777
VL - 4
SP - 147
EP - 153
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
SN - 1740-6757
IS - 3
ER -