In silico modeling of nitric oxide production, transport and consumption in the lungs

David A. Shelley, Hye Won Shin, Steven George

Research output: Contribution to journalReview article

Abstract

Nitric oxide (NO) mediates a vast array of physiological functions in the lungs, and our understanding of these events has improved dramatically over the past decade. Once produced enzymatically and intracellularly, NO can diffuse as a free molecule, or undergo chemical reactions to preserve and alter the biological activity. In silico modeling of these non-linear, multiscale and dynamic processes plays a crucial role in our understanding of, and thus our ability to manipulate, these events to treat pulmonary disease.

Original languageEnglish (US)
Pages (from-to)147-153
Number of pages7
JournalDrug Discovery Today: Disease Models
Volume4
Issue number3
DOIs
StatePublished - Sep 1 2007

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Computer Simulation
Nitric Oxide
Lung
Nonlinear Dynamics
Lung Diseases

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

In silico modeling of nitric oxide production, transport and consumption in the lungs. / Shelley, David A.; Shin, Hye Won; George, Steven.

In: Drug Discovery Today: Disease Models, Vol. 4, No. 3, 01.09.2007, p. 147-153.

Research output: Contribution to journalReview article

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