In silico modeling of nitric oxide production, transport and consumption in the lungs

David A. Shelley; Hye Won Shin; Steven George

doi:10.1016/j.ddmod.2007.06.006

In silico modeling of nitric oxide production, transport and consumption in the lungs

David A. Shelley, Hye Won Shin, Steven George

Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

Abstract

Nitric oxide (NO) mediates a vast array of physiological functions in the lungs, and our understanding of these events has improved dramatically over the past decade. Once produced enzymatically and intracellularly, NO can diffuse as a free molecule, or undergo chemical reactions to preserve and alter the biological activity. In silico modeling of these non-linear, multiscale and dynamic processes plays a crucial role in our understanding of, and thus our ability to manipulate, these events to treat pulmonary disease.

Original language	English (US)
Pages (from-to)	147-153
Number of pages	7
Journal	Drug Discovery Today: Disease Models
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.ddmod.2007.06.006
State	Published - Sep 1 2007

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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