In silico modeling of nitric oxide production, transport and consumption in the lungs

David A. Shelley, Hye Won Shin, Steven George

Research output: Contribution to journalReview article


Nitric oxide (NO) mediates a vast array of physiological functions in the lungs, and our understanding of these events has improved dramatically over the past decade. Once produced enzymatically and intracellularly, NO can diffuse as a free molecule, or undergo chemical reactions to preserve and alter the biological activity. In silico modeling of these non-linear, multiscale and dynamic processes plays a crucial role in our understanding of, and thus our ability to manipulate, these events to treat pulmonary disease.

Original languageEnglish (US)
Pages (from-to)147-153
Number of pages7
JournalDrug Discovery Today: Disease Models
Issue number3
StatePublished - Sep 1 2007


ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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