TY - JOUR
T1 - In silico modeling of nitric oxide production, transport and consumption in the lungs
AU - Shelley, David A.
AU - Shin, Hye Won
AU - George, Steven
PY - 2007/9/1
Y1 - 2007/9/1
N2 - Nitric oxide (NO) mediates a vast array of physiological functions in the lungs, and our understanding of these events has improved dramatically over the past decade. Once produced enzymatically and intracellularly, NO can diffuse as a free molecule, or undergo chemical reactions to preserve and alter the biological activity. In silico modeling of these non-linear, multiscale and dynamic processes plays a crucial role in our understanding of, and thus our ability to manipulate, these events to treat pulmonary disease.
AB - Nitric oxide (NO) mediates a vast array of physiological functions in the lungs, and our understanding of these events has improved dramatically over the past decade. Once produced enzymatically and intracellularly, NO can diffuse as a free molecule, or undergo chemical reactions to preserve and alter the biological activity. In silico modeling of these non-linear, multiscale and dynamic processes plays a crucial role in our understanding of, and thus our ability to manipulate, these events to treat pulmonary disease.
UR - http://www.scopus.com/inward/record.url?scp=42049110777&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42049110777&partnerID=8YFLogxK
U2 - 10.1016/j.ddmod.2007.06.006
DO - 10.1016/j.ddmod.2007.06.006
M3 - Review article
AN - SCOPUS:42049110777
VL - 4
SP - 147
EP - 153
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
SN - 1740-6757
IS - 3
ER -