In silico modeling of nitric oxide production, transport and consumption in the lungs

Nitric oxide (NO) mediates a vast array of physiological functions in the lungs, and our understanding of these events has improved dramatically over the past decade. Once produced enzymatically and intracellularly, NO can diffuse as a free molecule, or undergo chemical reactions to preserve and alter the biological activity. In silico modeling of these non-linear, multiscale and dynamic processes plays a crucial role in our understanding of, and thus our ability to manipulate, these events to treat pulmonary disease.