Abstract
Nitric oxide (NO) mediates a vast array of physiological functions in the lungs, and our understanding of these events has improved dramatically over the past decade. Once produced enzymatically and intracellularly, NO can diffuse as a free molecule, or undergo chemical reactions to preserve and alter the biological activity. In silico modeling of these non-linear, multiscale and dynamic processes plays a crucial role in our understanding of, and thus our ability to manipulate, these events to treat pulmonary disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 147-153 |
| Number of pages | 7 |
| Journal | Drug Discovery Today: Disease Models |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2007 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
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Cite this
Shelley, D. A., Shin, H. W., & George, S. (2007). In silico modeling of nitric oxide production, transport and consumption in the lungs. Drug Discovery Today: Disease Models, 4(3), 147-153. https://doi.org/10.1016/j.ddmod.2007.06.006