In silico genetics: Identification of a functional elements regulating HZ-Eα gene expression

Guochun Liao, Jianmei Wang, Jingshu Guo, John Allard, Janet Cheng, Anh Ng, Steve Shafer, Anne Puech, John Douglas Mcpherson, Dorothee Foernzler, Gary Peltz, Jonathan Usuka

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

Computational tools can markedly accelerate the rate at which murine genetic models can be analyzed. We developed a computational method for mapping phenotypic traits that vary among inbred strains onto haplotypic blocks. This method correctly predicted the genetic basis for strain-specific differences in several biologically important traits: It was also used to identify an allele-specific functional genomic element regulating H2-Eα gene expression. This functional element, which contained the binding sites for YY1 and a second transcription factor that is probably serum response factor, is located within the first intron of the H2-Eα gene. This computational method will greatly improve our ability to identify the genetic basis for a variety of phenotypic traits, ranging from qualitative trait information to quantitative gene expression data, which vary among inbred mouse strains.

Original languageEnglish (US)
Pages (from-to)690-695
Number of pages6
JournalScience
Volume306
Issue number5696
DOIs
StatePublished - Oct 22 2004
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Liao, G., Wang, J., Guo, J., Allard, J., Cheng, J., Ng, A., Shafer, S., Puech, A., Mcpherson, J. D., Foernzler, D., Peltz, G., & Usuka, J. (2004). In silico genetics: Identification of a functional elements regulating HZ-Eα gene expression. Science, 306(5696), 690-695. https://doi.org/10.1126/science.1100636