In silico genetics: Identification of a functional elements regulating HZ-Eα gene expression

Guochun Liao, Jianmei Wang, Jingshu Guo, John Allard, Janet Cheng, Anh Ng, Steve Shafer, Anne Puech, John Douglas Mcpherson, Dorothee Foernzler, Gary Peltz, Jonathan Usuka

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Computational tools can markedly accelerate the rate at which murine genetic models can be analyzed. We developed a computational method for mapping phenotypic traits that vary among inbred strains onto haplotypic blocks. This method correctly predicted the genetic basis for strain-specific differences in several biologically important traits: It was also used to identify an allele-specific functional genomic element regulating H2-Eα gene expression. This functional element, which contained the binding sites for YY1 and a second transcription factor that is probably serum response factor, is located within the first intron of the H2-Eα gene. This computational method will greatly improve our ability to identify the genetic basis for a variety of phenotypic traits, ranging from qualitative trait information to quantitative gene expression data, which vary among inbred mouse strains.

Original languageEnglish (US)
Pages (from-to)690-695
Number of pages6
JournalScience
Volume306
Issue number5696
DOIs
StatePublished - Oct 22 2004
Externally publishedYes

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Computer Simulation
Gene Expression
Serum Response Factor
Inbred Strains Mice
Genetic Models
Introns
Transcription Factors
Alleles
Binding Sites
Genes

ASJC Scopus subject areas

  • General

Cite this

Liao, G., Wang, J., Guo, J., Allard, J., Cheng, J., Ng, A., ... Usuka, J. (2004). In silico genetics: Identification of a functional elements regulating HZ-Eα gene expression. Science, 306(5696), 690-695. https://doi.org/10.1126/science.1100636

In silico genetics : Identification of a functional elements regulating HZ-Eα gene expression. / Liao, Guochun; Wang, Jianmei; Guo, Jingshu; Allard, John; Cheng, Janet; Ng, Anh; Shafer, Steve; Puech, Anne; Mcpherson, John Douglas; Foernzler, Dorothee; Peltz, Gary; Usuka, Jonathan.

In: Science, Vol. 306, No. 5696, 22.10.2004, p. 690-695.

Research output: Contribution to journalArticle

Liao, G, Wang, J, Guo, J, Allard, J, Cheng, J, Ng, A, Shafer, S, Puech, A, Mcpherson, JD, Foernzler, D, Peltz, G & Usuka, J 2004, 'In silico genetics: Identification of a functional elements regulating HZ-Eα gene expression', Science, vol. 306, no. 5696, pp. 690-695. https://doi.org/10.1126/science.1100636
Liao, Guochun ; Wang, Jianmei ; Guo, Jingshu ; Allard, John ; Cheng, Janet ; Ng, Anh ; Shafer, Steve ; Puech, Anne ; Mcpherson, John Douglas ; Foernzler, Dorothee ; Peltz, Gary ; Usuka, Jonathan. / In silico genetics : Identification of a functional elements regulating HZ-Eα gene expression. In: Science. 2004 ; Vol. 306, No. 5696. pp. 690-695.
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