Improving nanoprobes using surface-enhanced Raman scattering from 30-nm hollow gold particles

Adam M. Schwartzberg, Tammy Y. Oshiro, Jin Z. Zhang, Thomas R Huser, Chad E. Talley

Research output: Contribution to journalArticle

169 Scopus citations

Abstract

We report the development of nanoprobes that exploit the surface-enhanced Raman scattering (SERS) from nonaggregated, hollow, gold nanospheres (HGNSs). The homogeneity of the HGNSs leads to a nearly 10-fold improvement in signal consistency over standard silver SERS substrates, which translates into a significant increase in sensitivity and dynamic range for the model application of pH sensing. Moreover, the small size (30-nm diameter) of these SERS-active nanoparticles represents a major step in advancing sensing technology based on SERS, making this technology more amenable to intracellular sensing.

Original languageEnglish (US)
Pages (from-to)4732-4736
Number of pages5
JournalAnalytical Chemistry
Volume78
Issue number13
DOIs
StatePublished - Jul 1 2006

ASJC Scopus subject areas

  • Analytical Chemistry

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    Schwartzberg, A. M., Oshiro, T. Y., Zhang, J. Z., Huser, T. R., & Talley, C. E. (2006). Improving nanoprobes using surface-enhanced Raman scattering from 30-nm hollow gold particles. Analytical Chemistry, 78(13), 4732-4736. https://doi.org/10.1021/ac060220g