Improvement of reduced left ventricular diastolic compliance in ischemic heart disease after successful coronary artery bypass surgery

Richard R. Miller, Anthony N. DeMaria, Ezra A Amsterdam, Mary M. Mailander, Robert Zelis, Arthur J. Lurie, Dean T. Mason

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

To determine the effects of myocardial revascularization on decreased left ventricular diastolic compliance consequent to chronic stable coronary artery disease, 15 patients with patent coronary artery bypass grafts (Group I) were compared with 8 patients with occluded grafts (Group II) studied before and after operation. In addition, eight normal patients served as controls. Left ventricular diastolic compliance was assessed by: (1) total observed diastolic compliance: stroke volume (V) related to left ventricular diastolic pressure (P) change (ΔV/ΔP) normalized for end-systolic volume; (2) left ventricular stiffness index of passive elastic modulus (a = slope of ΔV/ΔP related to mean left ventricular diastolic pressure); and (3) fractional pattern of left ventricular filling. All patients had normal sinus rhythm and none had preoperative or postoperative mitral regurgitation. The two groups with coronary disease were well matched preoperatively for ventricular function, volumes, mass, segmental contraction and compliance. Ejection fraction increased in Group I (0.56 preoperatively to 0.65 postoperatively, P < 0.05) but was unchanged in Group II (0.63 to 0.61, P > 0.05). Postoperative indexes of left ventricular compliance improved in Group I: (1) 0.110 to 0.150 (P < 0.05); (2) 0.030 to 0.019 (P < 0.05); and (3) 37 to 30 percent filling during last one third of diastole (P < 0.05). These indexes were unchanged postoperatively in Group II: (1) 0.109 to 0.102 (P > 0.05); (2) 0.033 to 0.039 (P > 0.05); and (3) 36 to 41 percent (P > 0.05). Compliance indexes were not altered (P > 0.05) in a subset of seven patients in Group I with preoperative or intercurrent myocardial infarction. Thus, this investigation demonstrates the relatively reversible nature of abnormal left ventricular compliance after successful coronary artery bypass surgery in certain patients with ischemic heart disease.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalThe American journal of cardiology
Volume35
Issue number1
DOIs
StatePublished - 1975

Fingerprint

Coronary Artery Bypass
Compliance
Myocardial Ischemia
Ventricular Pressure
Blood Pressure
Transplants
Myocardial Revascularization
Ventricular Function
Elastic Modulus
Mitral Valve Insufficiency
Stroke Volume
Coronary Disease
Coronary Artery Disease
Myocardial Infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Improvement of reduced left ventricular diastolic compliance in ischemic heart disease after successful coronary artery bypass surgery. / Miller, Richard R.; DeMaria, Anthony N.; Amsterdam, Ezra A; Mailander, Mary M.; Zelis, Robert; Lurie, Arthur J.; Mason, Dean T.

In: The American journal of cardiology, Vol. 35, No. 1, 1975, p. 11-16.

Research output: Contribution to journalArticle

Miller, Richard R. ; DeMaria, Anthony N. ; Amsterdam, Ezra A ; Mailander, Mary M. ; Zelis, Robert ; Lurie, Arthur J. ; Mason, Dean T. / Improvement of reduced left ventricular diastolic compliance in ischemic heart disease after successful coronary artery bypass surgery. In: The American journal of cardiology. 1975 ; Vol. 35, No. 1. pp. 11-16.
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