Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats

Tzu Cheng Lee, Andrew J. Burghardt, Wei Yao, Nancy E Lane, Sharmila Majumdar, Grant T. Gullberg, Youngho Seo

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A few clinical studies have reported that elderly male participants with hypertensive disease frequently have higher bone mineral density (BMD) than the normotensive participants at several skeletal sites. The detailed mechanism is still unknown; therefore, a study of bone structure and density using the hypertensive animal models could be informative. We used micro-computed tomography to quantitatively evaluate the tibial and 3rd lumbar vertebral bones in the 20-month-old male spontaneous hypertensive rat (SHR). The BMD, volume fraction, and the microarchitecture changes of the SHR were compared to those of same-age normotensive controls (Wistar-Kyoto rat, WKY). We found that in the very old (20 month) male rats, the trabecular bone fraction and microstructure were higher than those in the same-age normotensive controls. The observation of the association of hypertension with BMD and bone strength in hypertensive rats warrants further investigations of bone mass and strength in elderly males with hypertension.

Original languageEnglish (US)
Pages (from-to)282-291
Number of pages10
JournalCalcified Tissue International
Issue number3
StatePublished - 2014


  • Aging
  • Bone strength
  • Hypertension
  • Quantitative micro-CT
  • Spontaneous hypertensive rat
  • Trabecular structure

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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