Improved regional control and survival with "low Maruyama Index" surgery in gastric cancer: Autopsy findings from the Dutch D1-D2 Trial

Scott A Hundahl, Koen C M J Peeters, E. Klein Kranenbarg, Henk Hartgrink, Cornelis J H Van De Velde

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Based on more than 11 years of follow-up, autopsy-based analysis of recurrence in the Dutch D1-D2 Trial permits meaningful assessment of patterns of failure with respect to the Maruyama Index (MI). We previously reported that a low Maruyama Index was an independent predictor of both overall and disease-specific survival. Autopsy results are available for 441 deaths on study. Distant-only failure (15% vs 13%) was no different between the MI categories, but isolated "regional" failure (8% for MI < 5 group vs 21%) and "regional + distant" failure (19% for MI < 5 group vs 36%) occurred less frequently in the MI < 5 group (P < 0.001). We conclude that "low Maruyama Index" surgery enhances regional control and survival but does not alter the occurrence of isolated distant metastases unassociated with regional failure. Our results speak to the substantial survival value of local-regional control in this disease.

Original languageEnglish (US)
Pages (from-to)84-86
Number of pages3
JournalGastric Cancer
Volume10
Issue number2
DOIs
StatePublished - Jun 2007

Keywords

  • Autopsy
  • Computer
  • Gastric cancer
  • Lymphadenectomy
  • Maruyama Index
  • Node
  • Pattern of failure
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Cancer Research

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