Abstract
Transcutaneous osseointegrated prostheses provide stable connections to the skeleton while eliminating skin lesions experienced with socket prosthetics. Additive manufacturing can create custom textured implants capable of interfacing with amputees’ residual bones. Our objective was to compare osseointegration of textured surface implants made by electron beam melting (EBM), an additive manufacturing process, to machine threaded implants. Whole body vibration was investigated to accelerate osseointegration. Two cohorts of Sprague-Dawley rats received bilateral, titanium implants (EBM vs. threaded) in their tibiae. One cohort comprising five groups vibrated at 45 Hz: 0.0 (control), 0.15, 0.3, 0.6 or 1.2 g was followed for six weeks. Osseointegration was evaluated through torsional testing and bone volume fraction (BV/TV). A second cohort, divided into two groups (control and 0.6 g), was followed for 24 days and evaluated for resonant frequency, bone-implant contact (BIC) and fluorochrome labeling. The EBM textured implants exhibited significantly improved mechanical stability independent of vibration, highlighting the benefits of using EBM to produce custom textured surfaces. Bone formation on and around the EBM textured implants increased compared to machined implants, as seen by BIC and fluorescence. No difference in torque, BIC or fluorescence among vibration levels was detected. BV/TV significantly increased at 0.6 g compared to control for both implant types.
| Original language | English (US) |
|---|---|
| Journal | Medical Engineering and Physics |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- Additive manufactured implants
- Bone-implant interface
- Electron beam melting
- Osseointegration of Transcutaneous Prostheses
- Textured implant
- Whole Body Vibration
ASJC Scopus subject areas
- Biophysics
- Biomedical Engineering
Cite this
Improved osseointegration with as-built electron beam melted textured implants and improved peri‑implant bone volume with whole body vibration. / Ruppert, David S.; Harrysson, Ola L.A.; Marcellin-Little, Denis J; Dahners, Laurence E.; Weinhold, Paul S.
In: Medical Engineering and Physics, 01.01.2018.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Improved osseointegration with as-built electron beam melted textured implants and improved peri‑implant bone volume with whole body vibration
AU - Ruppert, David S.
AU - Harrysson, Ola L.A.
AU - Marcellin-Little, Denis J
AU - Dahners, Laurence E.
AU - Weinhold, Paul S.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Transcutaneous osseointegrated prostheses provide stable connections to the skeleton while eliminating skin lesions experienced with socket prosthetics. Additive manufacturing can create custom textured implants capable of interfacing with amputees’ residual bones. Our objective was to compare osseointegration of textured surface implants made by electron beam melting (EBM), an additive manufacturing process, to machine threaded implants. Whole body vibration was investigated to accelerate osseointegration. Two cohorts of Sprague-Dawley rats received bilateral, titanium implants (EBM vs. threaded) in their tibiae. One cohort comprising five groups vibrated at 45 Hz: 0.0 (control), 0.15, 0.3, 0.6 or 1.2 g was followed for six weeks. Osseointegration was evaluated through torsional testing and bone volume fraction (BV/TV). A second cohort, divided into two groups (control and 0.6 g), was followed for 24 days and evaluated for resonant frequency, bone-implant contact (BIC) and fluorochrome labeling. The EBM textured implants exhibited significantly improved mechanical stability independent of vibration, highlighting the benefits of using EBM to produce custom textured surfaces. Bone formation on and around the EBM textured implants increased compared to machined implants, as seen by BIC and fluorescence. No difference in torque, BIC or fluorescence among vibration levels was detected. BV/TV significantly increased at 0.6 g compared to control for both implant types.
AB - Transcutaneous osseointegrated prostheses provide stable connections to the skeleton while eliminating skin lesions experienced with socket prosthetics. Additive manufacturing can create custom textured implants capable of interfacing with amputees’ residual bones. Our objective was to compare osseointegration of textured surface implants made by electron beam melting (EBM), an additive manufacturing process, to machine threaded implants. Whole body vibration was investigated to accelerate osseointegration. Two cohorts of Sprague-Dawley rats received bilateral, titanium implants (EBM vs. threaded) in their tibiae. One cohort comprising five groups vibrated at 45 Hz: 0.0 (control), 0.15, 0.3, 0.6 or 1.2 g was followed for six weeks. Osseointegration was evaluated through torsional testing and bone volume fraction (BV/TV). A second cohort, divided into two groups (control and 0.6 g), was followed for 24 days and evaluated for resonant frequency, bone-implant contact (BIC) and fluorochrome labeling. The EBM textured implants exhibited significantly improved mechanical stability independent of vibration, highlighting the benefits of using EBM to produce custom textured surfaces. Bone formation on and around the EBM textured implants increased compared to machined implants, as seen by BIC and fluorescence. No difference in torque, BIC or fluorescence among vibration levels was detected. BV/TV significantly increased at 0.6 g compared to control for both implant types.
KW - Additive manufactured implants
KW - Bone-implant interface
KW - Electron beam melting
KW - Osseointegration of Transcutaneous Prostheses
KW - Textured implant
KW - Whole Body Vibration
UR - http://www.scopus.com/inward/record.url?scp=85048262601&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048262601&partnerID=8YFLogxK
U2 - 10.1016/j.medengphy.2018.05.003
DO - 10.1016/j.medengphy.2018.05.003
M3 - Article
AN - SCOPUS:85048262601
JO - Medical Engineering and Physics
JF - Medical Engineering and Physics
SN - 1350-4533
ER -