Improved in vivo imaging of human blood circulation in the chorioretinal complex using phase variance method with new phase stabilized 1 μm swept-source optical coherence tomography (pv-SSOCT)

Raju Poddar, Dae Yu Kim, John S Werner, Robert Zawadzki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We demonstrate the feasibility of our newly developed phase stabilized high-speed (100 kHz A-scans/s) 1 μm sweptsource optical coherence tomography (SSOCT) system with the phase-variance based motion contrast method for visualization of human chorioretinal complex microcirculation. Compared to our previously reported spectral domain (spectrometer based) phase-variance (pv)-SDOCT system it has advantages of higher sensitivity, reduced fringe washout for high blood flow speeds and deeper penetration in choroid. High phase stability SSOCT imaging was achieved by using a computationally efficient phase stabilization approach. This process does not require additional calibration hardware and complex numerical procedures. Our phase stabilization method is simple and can be employed in a variety of SS-OCT systems. Examples of vasculature in the chorioretinal complex imaged by pv-SSOCT is presented and compared to retinal images of the same volunteers acquired with fluorescein angiography (FA) and indocyanine green angiography (ICGA).

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8930
ISBN (Print)9780819498434
DOIs
StatePublished - 2014
Event24th Conference on Ophthalmic Technologies - San Francisco, CA, United States
Duration: Feb 1 2014Feb 2 2014

Other

Other24th Conference on Ophthalmic Technologies
CountryUnited States
CitySan Francisco, CA
Period2/1/142/2/14

Keywords

  • Medical and biological imaging
  • Medical optics instrumentation
  • Ophthalmic optics and devices
  • Ophthalmology
  • Optical coherence tomography
  • Retinal blood flow

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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