Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck

Emi Yoshida, Rony Aouad, Ruben Fragoso, D. Gregory Farwell, Regina Gandour-Edwards, Paul J. Donald, Allen M. Chen

Research output: Contribution to journalArticle

23 Scopus citations


Objective: To examine outcomes among patients treated for sinonasal undifferentiated carcinoma (SNUC) of the head and neck. Study design Retrospective review. Methods: The records of 16 consecutive patients with newly diagnosed, non-metastatic SNUC were analyzed. Initial treatment consisted of: surgery alone (6 patients), surgery with post-operative chemoradiotherapy (4 patients), and primary radiation therapy with concurrent chemotherapy (6 patients). Results: The median survival for patients treated by surgery followed by postoperative chemoradiotherapy was 30 months compared to 7 months and 9 months for patients treated by surgery alone and upfront chemoradiotherapy, respectively (p = 0.20). The 2-year locoregional control was 18% for patients treated with upfront chemoradiotherapy, 37% for patients treated with surgery alone, and 78% for patients treated with surgery plus chemoradiotherapy (p = 0.49). Conclusion While the potential role of selection bias must be considered, multi-modality therapy using surgery and post-operative chemoradiotherapy yielded the most favorable outcomes for SNUC and should be recommended whenever feasible.

Original languageEnglish (US)
Pages (from-to)658-663
Number of pages6
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Issue number6
StatePublished - Nov 2013


ASJC Scopus subject areas

  • Otorhinolaryngology

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