Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck

Emi Yoshida, Rony Aouad, Ruben Fragoso, D. Gregory Farwell, Regina Gandour-Edwards, Paul J. Donald, Allen M. Chen

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19 Citations (Scopus)

Abstract

Objective: To examine outcomes among patients treated for sinonasal undifferentiated carcinoma (SNUC) of the head and neck. Study design Retrospective review. Methods: The records of 16 consecutive patients with newly diagnosed, non-metastatic SNUC were analyzed. Initial treatment consisted of: surgery alone (6 patients), surgery with post-operative chemoradiotherapy (4 patients), and primary radiation therapy with concurrent chemotherapy (6 patients). Results: The median survival for patients treated by surgery followed by postoperative chemoradiotherapy was 30 months compared to 7 months and 9 months for patients treated by surgery alone and upfront chemoradiotherapy, respectively (p = 0.20). The 2-year locoregional control was 18% for patients treated with upfront chemoradiotherapy, 37% for patients treated with surgery alone, and 78% for patients treated with surgery plus chemoradiotherapy (p = 0.49). Conclusion While the potential role of selection bias must be considered, multi-modality therapy using surgery and post-operative chemoradiotherapy yielded the most favorable outcomes for SNUC and should be recommended whenever feasible.

Original languageEnglish (US)
Pages (from-to)658-663
Number of pages6
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume34
Issue number6
DOIs
StatePublished - Nov 2013

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Neck
Head
Chemoradiotherapy
Therapeutics
Sinonasal undifferentiated carcinoma
Selection Bias
Radiotherapy
Retrospective Studies
Drug Therapy
Survival

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

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title = "Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck",
abstract = "Objective: To examine outcomes among patients treated for sinonasal undifferentiated carcinoma (SNUC) of the head and neck. Study design Retrospective review. Methods: The records of 16 consecutive patients with newly diagnosed, non-metastatic SNUC were analyzed. Initial treatment consisted of: surgery alone (6 patients), surgery with post-operative chemoradiotherapy (4 patients), and primary radiation therapy with concurrent chemotherapy (6 patients). Results: The median survival for patients treated by surgery followed by postoperative chemoradiotherapy was 30 months compared to 7 months and 9 months for patients treated by surgery alone and upfront chemoradiotherapy, respectively (p = 0.20). The 2-year locoregional control was 18{\%} for patients treated with upfront chemoradiotherapy, 37{\%} for patients treated with surgery alone, and 78{\%} for patients treated with surgery plus chemoradiotherapy (p = 0.49). Conclusion While the potential role of selection bias must be considered, multi-modality therapy using surgery and post-operative chemoradiotherapy yielded the most favorable outcomes for SNUC and should be recommended whenever feasible.",
author = "Emi Yoshida and Rony Aouad and Ruben Fragoso and Farwell, {D. Gregory} and Regina Gandour-Edwards and Donald, {Paul J.} and Chen, {Allen M.}",
year = "2013",
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doi = "10.1016/j.amjoto.2013.06.005",
language = "English (US)",
volume = "34",
pages = "658--663",
journal = "American Journal of Otolaryngology - Head and Neck Medicine and Surgery",
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TY - JOUR

T1 - Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck

AU - Yoshida, Emi

AU - Aouad, Rony

AU - Fragoso, Ruben

AU - Farwell, D. Gregory

AU - Gandour-Edwards, Regina

AU - Donald, Paul J.

AU - Chen, Allen M.

PY - 2013/11

Y1 - 2013/11

N2 - Objective: To examine outcomes among patients treated for sinonasal undifferentiated carcinoma (SNUC) of the head and neck. Study design Retrospective review. Methods: The records of 16 consecutive patients with newly diagnosed, non-metastatic SNUC were analyzed. Initial treatment consisted of: surgery alone (6 patients), surgery with post-operative chemoradiotherapy (4 patients), and primary radiation therapy with concurrent chemotherapy (6 patients). Results: The median survival for patients treated by surgery followed by postoperative chemoradiotherapy was 30 months compared to 7 months and 9 months for patients treated by surgery alone and upfront chemoradiotherapy, respectively (p = 0.20). The 2-year locoregional control was 18% for patients treated with upfront chemoradiotherapy, 37% for patients treated with surgery alone, and 78% for patients treated with surgery plus chemoradiotherapy (p = 0.49). Conclusion While the potential role of selection bias must be considered, multi-modality therapy using surgery and post-operative chemoradiotherapy yielded the most favorable outcomes for SNUC and should be recommended whenever feasible.

AB - Objective: To examine outcomes among patients treated for sinonasal undifferentiated carcinoma (SNUC) of the head and neck. Study design Retrospective review. Methods: The records of 16 consecutive patients with newly diagnosed, non-metastatic SNUC were analyzed. Initial treatment consisted of: surgery alone (6 patients), surgery with post-operative chemoradiotherapy (4 patients), and primary radiation therapy with concurrent chemotherapy (6 patients). Results: The median survival for patients treated by surgery followed by postoperative chemoradiotherapy was 30 months compared to 7 months and 9 months for patients treated by surgery alone and upfront chemoradiotherapy, respectively (p = 0.20). The 2-year locoregional control was 18% for patients treated with upfront chemoradiotherapy, 37% for patients treated with surgery alone, and 78% for patients treated with surgery plus chemoradiotherapy (p = 0.49). Conclusion While the potential role of selection bias must be considered, multi-modality therapy using surgery and post-operative chemoradiotherapy yielded the most favorable outcomes for SNUC and should be recommended whenever feasible.

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