Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke

Renée J. Turner, Frank R Sharp

Research output: Contribution to journalReview articlepeer-review

171 Scopus citations

Abstract

Numerous studies have documented increases in matrix metalloproteinases (MMPs), specifically MMP-9 levels following stroke, with such perturbations associated with disruption of the blood brain barrier (BBB), increased risk of hemorrhagic complications, and worsened outcome. Despite this, controversy remains as to which cells release MMP-9 at the normal and pathological BBB, with even less clarity in the context of stroke. This may be further complicated by the influence of tissue plasminogen activator (tPA) treatment. The aim of the present review is to examine the relationship between neutrophils, MMP-9 and tPA following ischemic stroke to elucidate which cells are responsible for the increases in MMP-9 and resultant barrier changes and hemorrhage observed following stroke.

Original languageEnglish (US)
Article number56
JournalFrontiers in Cellular Neuroscience
Volume10
Issue numberMAR2016
DOIs
StatePublished - Mar 4 2016

Keywords

  • Blood-brain barrier
  • Cerebral edema
  • Hemorrhagic transformation
  • Ischemic stroke
  • MMP-9
  • Neutrophils
  • TPA

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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