Implications of microbiota and bile acid in liver injury and regeneration

Hui Xin Liu, Ryan Keane, Lili Sheng, Yu-Jui Yvonne Wan

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Summary Studies examining the mechanisms by which the liver incurs injury and then regenerates usually focus on factors and pathways directly within the liver, neglecting the signaling derived from the gut-liver axis. The intestinal content is rich in microorganisms as well as metabolites generated from both the host and colonizing bacteria. Through the gut-liver axis, this complex "soup" exerts an immense impact on liver integrity and function. This review article summarizes data published in the past 30 years demonstrating the signaling derived from the gut-liver axis in relation to liver injury and regeneration. Due to the intricate networks of implicated pathways as well as scarcity of available mechanistic data, it seems that nutrigenomic, metabolomics, and microbiota profiling approaches are warranted to provide a better understanding regarding the interplay and impact between nutrition, bacteria, and host response in influencing liver function and healing. Therefore elucidating the possible molecular mechanisms that link microbiota alteration to host physiological response and vice versa.

Original languageEnglish (US)
Pages (from-to)1502-1510
Number of pages9
JournalJournal of Hepatology
Volume63
Issue number6
DOIs
StatePublished - Dec 1 2015

Fingerprint

Liver Regeneration
Microbiota
Bile Acids and Salts
Liver
Wounds and Injuries
Nutrigenomics
Bacteria
Gastrointestinal Contents
Metabolomics

Keywords

  • Bile acid receptor
  • FXR
  • Gut dysbiosis
  • Gut-liver axis
  • Nuclear receptor
  • Partial hepatectomy
  • Prebiotic
  • Probiotic

ASJC Scopus subject areas

  • Hepatology

Cite this

Implications of microbiota and bile acid in liver injury and regeneration. / Liu, Hui Xin; Keane, Ryan; Sheng, Lili; Wan, Yu-Jui Yvonne.

In: Journal of Hepatology, Vol. 63, No. 6, 01.12.2015, p. 1502-1510.

Research output: Contribution to journalArticle

Liu, Hui Xin ; Keane, Ryan ; Sheng, Lili ; Wan, Yu-Jui Yvonne. / Implications of microbiota and bile acid in liver injury and regeneration. In: Journal of Hepatology. 2015 ; Vol. 63, No. 6. pp. 1502-1510.
@article{3901d9c6293b4275a78f806d333d2753,
title = "Implications of microbiota and bile acid in liver injury and regeneration",
abstract = "Summary Studies examining the mechanisms by which the liver incurs injury and then regenerates usually focus on factors and pathways directly within the liver, neglecting the signaling derived from the gut-liver axis. The intestinal content is rich in microorganisms as well as metabolites generated from both the host and colonizing bacteria. Through the gut-liver axis, this complex {"}soup{"} exerts an immense impact on liver integrity and function. This review article summarizes data published in the past 30 years demonstrating the signaling derived from the gut-liver axis in relation to liver injury and regeneration. Due to the intricate networks of implicated pathways as well as scarcity of available mechanistic data, it seems that nutrigenomic, metabolomics, and microbiota profiling approaches are warranted to provide a better understanding regarding the interplay and impact between nutrition, bacteria, and host response in influencing liver function and healing. Therefore elucidating the possible molecular mechanisms that link microbiota alteration to host physiological response and vice versa.",
keywords = "Bile acid receptor, FXR, Gut dysbiosis, Gut-liver axis, Nuclear receptor, Partial hepatectomy, Prebiotic, Probiotic",
author = "Liu, {Hui Xin} and Ryan Keane and Lili Sheng and Wan, {Yu-Jui Yvonne}",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.jhep.2015.08.001",
language = "English (US)",
volume = "63",
pages = "1502--1510",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - Implications of microbiota and bile acid in liver injury and regeneration

AU - Liu, Hui Xin

AU - Keane, Ryan

AU - Sheng, Lili

AU - Wan, Yu-Jui Yvonne

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Summary Studies examining the mechanisms by which the liver incurs injury and then regenerates usually focus on factors and pathways directly within the liver, neglecting the signaling derived from the gut-liver axis. The intestinal content is rich in microorganisms as well as metabolites generated from both the host and colonizing bacteria. Through the gut-liver axis, this complex "soup" exerts an immense impact on liver integrity and function. This review article summarizes data published in the past 30 years demonstrating the signaling derived from the gut-liver axis in relation to liver injury and regeneration. Due to the intricate networks of implicated pathways as well as scarcity of available mechanistic data, it seems that nutrigenomic, metabolomics, and microbiota profiling approaches are warranted to provide a better understanding regarding the interplay and impact between nutrition, bacteria, and host response in influencing liver function and healing. Therefore elucidating the possible molecular mechanisms that link microbiota alteration to host physiological response and vice versa.

AB - Summary Studies examining the mechanisms by which the liver incurs injury and then regenerates usually focus on factors and pathways directly within the liver, neglecting the signaling derived from the gut-liver axis. The intestinal content is rich in microorganisms as well as metabolites generated from both the host and colonizing bacteria. Through the gut-liver axis, this complex "soup" exerts an immense impact on liver integrity and function. This review article summarizes data published in the past 30 years demonstrating the signaling derived from the gut-liver axis in relation to liver injury and regeneration. Due to the intricate networks of implicated pathways as well as scarcity of available mechanistic data, it seems that nutrigenomic, metabolomics, and microbiota profiling approaches are warranted to provide a better understanding regarding the interplay and impact between nutrition, bacteria, and host response in influencing liver function and healing. Therefore elucidating the possible molecular mechanisms that link microbiota alteration to host physiological response and vice versa.

KW - Bile acid receptor

KW - FXR

KW - Gut dysbiosis

KW - Gut-liver axis

KW - Nuclear receptor

KW - Partial hepatectomy

KW - Prebiotic

KW - Probiotic

UR - http://www.scopus.com/inward/record.url?scp=84951209574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84951209574&partnerID=8YFLogxK

U2 - 10.1016/j.jhep.2015.08.001

DO - 10.1016/j.jhep.2015.08.001

M3 - Article

C2 - 26256437

AN - SCOPUS:84951209574

VL - 63

SP - 1502

EP - 1510

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 6

ER -