Implications of activity-dependent neurotransmitter-receptor matching

Nicholas C. Spitzer, Laura N Borodinsky

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Electrical activity has numerous roles in early neuronal development. Calcium transients generated at low frequencies regulate neural induction and neuronal proliferation, migration and differentiation. Recent work demonstrates that these signals participate in specification of the transmitters expressed in different classes of neurons. Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and evolution of the nervous system.

Original languageEnglish (US)
Pages (from-to)1393-1399
Number of pages7
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Issue number1495
StatePublished - Apr 12 2008


  • Calcium spikes
  • Homeostatic receptor plasticity
  • Neuromuscular junction
  • Neurotransmitter receptors
  • Neurotransmitters
  • Spinal cord

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)


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