Implications of activity-dependent neurotransmitter-receptor matching

Nicholas C. Spitzer; Laura N Borodinsky

doi:10.1098/rstb.2007.2257

Implications of activity-dependent neurotransmitter-receptor matching

Nicholas C. Spitzer, Laura N Borodinsky

Physiology and Membrane Biology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Electrical activity has numerous roles in early neuronal development. Calcium transients generated at low frequencies regulate neural induction and neuronal proliferation, migration and differentiation. Recent work demonstrates that these signals participate in specification of the transmitters expressed in different classes of neurons. Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and evolution of the nervous system.

Original language	English (US)
Pages (from-to)	1393-1399
Number of pages	7
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Volume	363
Issue number	1495
DOIs	https://doi.org/10.1098/rstb.2007.2257
State	Published - Apr 12 2008

Keywords

Calcium spikes
Homeostatic receptor plasticity
Neuromuscular junction
Neurotransmitter receptors
Neurotransmitters
Spinal cord

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Agricultural and Biological Sciences (miscellaneous)

Access to Document

10.1098/rstb.2007.2257

Cite this

@article{31847ca63bce455f8bd3278596ef2bec,

title = "Implications of activity-dependent neurotransmitter-receptor matching",

abstract = "Electrical activity has numerous roles in early neuronal development. Calcium transients generated at low frequencies regulate neural induction and neuronal proliferation, migration and differentiation. Recent work demonstrates that these signals participate in specification of the transmitters expressed in different classes of neurons. Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and evolution of the nervous system.",

keywords = "Calcium spikes, Homeostatic receptor plasticity, Neuromuscular junction, Neurotransmitter receptors, Neurotransmitters, Spinal cord",

author = "Spitzer, {Nicholas C.} and Borodinsky, {Laura N}",

year = "2008",

month = apr,

day = "12",

doi = "10.1098/rstb.2007.2257",

language = "English (US)",

volume = "363",

pages = "1393--1399",

journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",

issn = "0800-4622",

publisher = "Royal Society of London",

number = "1495",

}

TY - JOUR

T1 - Implications of activity-dependent neurotransmitter-receptor matching

AU - Spitzer, Nicholas C.

AU - Borodinsky, Laura N

PY - 2008/4/12

Y1 - 2008/4/12

N2 - Electrical activity has numerous roles in early neuronal development. Calcium transients generated at low frequencies regulate neural induction and neuronal proliferation, migration and differentiation. Recent work demonstrates that these signals participate in specification of the transmitters expressed in different classes of neurons. Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and evolution of the nervous system.

AB - Electrical activity has numerous roles in early neuronal development. Calcium transients generated at low frequencies regulate neural induction and neuronal proliferation, migration and differentiation. Recent work demonstrates that these signals participate in specification of the transmitters expressed in different classes of neurons. Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and evolution of the nervous system.

KW - Calcium spikes

KW - Homeostatic receptor plasticity

KW - Neuromuscular junction

KW - Neurotransmitter receptors

KW - Neurotransmitters

KW - Spinal cord

UR - http://www.scopus.com/inward/record.url?scp=39749150976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39749150976&partnerID=8YFLogxK

U2 - 10.1098/rstb.2007.2257

DO - 10.1098/rstb.2007.2257

M3 - Article

C2 - 18198155

AN - SCOPUS:39749150976

VL - 363

SP - 1393

EP - 1399

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

SN - 0800-4622

IS - 1495

ER -

Implications of activity-dependent neurotransmitter-receptor matching

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this