Implications of activity-dependent neurotransmitter-receptor matching

Nicholas C. Spitzer; Laura N Borodinsky

doi:10.1098/rstb.2007.2257

Implications of activity-dependent neurotransmitter-receptor matching

Nicholas C. Spitzer, Laura N Borodinsky

Physiology and Membrane Biology

Research output: Contribution to journal › Article

22 Scopus citations

Abstract

Electrical activity has numerous roles in early neuronal development. Calcium transients generated at low frequencies regulate neural induction and neuronal proliferation, migration and differentiation. Recent work demonstrates that these signals participate in specification of the transmitters expressed in different classes of neurons. Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and evolution of the nervous system.

Original language	English (US)
Pages (from-to)	1393-1399
Number of pages	7
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Volume	363
Issue number	1495
DOIs	https://doi.org/10.1098/rstb.2007.2257
State	Published - Apr 12 2008

Keywords

Calcium spikes
Homeostatic receptor plasticity
Neuromuscular junction
Neurotransmitter receptors
Neurotransmitters
Spinal cord

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Agricultural and Biological Sciences (miscellaneous)

Access to Document

10.1098/rstb.2007.2257

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Spitzer, N. C., & Borodinsky, L. N. (2008). Implications of activity-dependent neurotransmitter-receptor matching. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1495), 1393-1399. https://doi.org/10.1098/rstb.2007.2257

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