Abstract
Electrical activity has numerous roles in early neuronal development. Calcium transients generated at low frequencies regulate neural induction and neuronal proliferation, migration and differentiation. Recent work demonstrates that these signals participate in specification of the transmitters expressed in different classes of neurons. Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and evolution of the nervous system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1393-1399 |
| Number of pages | 7 |
| Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
| Volume | 363 |
| Issue number | 1495 |
| DOIs | |
| State | Published - Apr 12 2008 |
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Keywords
- Calcium spikes
- Homeostatic receptor plasticity
- Neuromuscular junction
- Neurotransmitter receptors
- Neurotransmitters
- Spinal cord
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Agricultural and Biological Sciences (miscellaneous)
Cite this
Implications of activity-dependent neurotransmitter-receptor matching. / Spitzer, Nicholas C.; Borodinsky, Laura N.
In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 363, No. 1495, 12.04.2008, p. 1393-1399.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Implications of activity-dependent neurotransmitter-receptor matching
AU - Spitzer, Nicholas C.
AU - Borodinsky, Laura N
PY - 2008/4/12
Y1 - 2008/4/12
N2 - Electrical activity has numerous roles in early neuronal development. Calcium transients generated at low frequencies regulate neural induction and neuronal proliferation, migration and differentiation. Recent work demonstrates that these signals participate in specification of the transmitters expressed in different classes of neurons. Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and evolution of the nervous system.
AB - Electrical activity has numerous roles in early neuronal development. Calcium transients generated at low frequencies regulate neural induction and neuronal proliferation, migration and differentiation. Recent work demonstrates that these signals participate in specification of the transmitters expressed in different classes of neurons. Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and evolution of the nervous system.
KW - Calcium spikes
KW - Homeostatic receptor plasticity
KW - Neuromuscular junction
KW - Neurotransmitter receptors
KW - Neurotransmitters
KW - Spinal cord
UR - http://www.scopus.com/inward/record.url?scp=39749150976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39749150976&partnerID=8YFLogxK
U2 - 10.1098/rstb.2007.2257
DO - 10.1098/rstb.2007.2257
M3 - Article
C2 - 18198155
AN - SCOPUS:39749150976
VL - 363
SP - 1393
EP - 1399
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
SN - 0800-4622
IS - 1495
ER -