Implant-stimulated interface reactions during collagenous bone matrix-induced bone formation

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32 Scopus citations


The sequential cellular reactions in the interface of collagenous bone matrix implants are described. The multistep cascade in response to bone matrix implantation include: binding of fibrin and fibronectin to the implanted matrix, chemotaxis of cells, proliferation of fibroblasts, differentiation into chondroblasts, cartilage formation, vascular invasion, bone formation, remodeling, and bone marrow differentiation. The mechanism of action is not known. However, several properties governing the implantcell interface are described. It is possible that bone matrix is a suitable biomaterial with potential applications in periodontal and orthopedic practice.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalJournal of Biomedical Materials Research
Issue number3
StatePublished - Mar 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials


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