Impedance biosensors

Applications to sustainability and remaining technical challenges

Rajeswaran Radhakrishnan, Ian I. Suni, Candace S. Bever, Bruce D. Hammock

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Due to their all-electrical nature, impedance biosensors have significant potential for use as simple and portable sensors for environmental studies and environmental monitoring. Detection of two endocrine-disrupting chemicals (EDC), norfluoxetine and BDE-47, is reported here by impedance biosensing, with a detection limit of 8.5 and 1.3 ng/mL for norfluoxetine and BDE-47, respectively. Although impedance biosensors have been widely studied in the academic literature, commercial applications have been hindered by several technical limitations, including possible limitations to small analytes, the complexity of impedance detection, susceptibility to nonspecific adsorption, and stability of biomolecule immobilization. Recent research into methods to overcome these obstacles is briefly reviewed. New results demonstrating antibody regeneration atop degenerate (highly doped) Si are also reported. Using 0.2 M KSCN and 10 mM HF for antibody regeneration, peanut protein Ara h 1 is detected daily during a 30 day trial.

Original languageEnglish (US)
Pages (from-to)1649-1655
Number of pages7
JournalACS Sustainable Chemistry and Engineering
Volume2
Issue number7
DOIs
StatePublished - Jul 7 2014

Fingerprint

Biosensors
Antibodies
Sustainable development
sustainability
Endocrine Disruptors
antibody
Biomolecules
regeneration
environmental monitoring
Proteins
Adsorption
immobilization
Monitoring
Sensors
sensor
adsorption
protein
2,2',4,4'-tetrabromodiphenyl ether
norfluoxetine
detection

Keywords

  • Biosensors
  • Electrochemical impedance spectroscopy
  • Endocrine-disrupting chemicals
  • Nanotechnology
  • Sustainability

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)
  • Renewable Energy, Sustainability and the Environment
  • Environmental Chemistry

Cite this

Impedance biosensors : Applications to sustainability and remaining technical challenges. / Radhakrishnan, Rajeswaran; Suni, Ian I.; Bever, Candace S.; Hammock, Bruce D.

In: ACS Sustainable Chemistry and Engineering, Vol. 2, No. 7, 07.07.2014, p. 1649-1655.

Research output: Contribution to journalArticle

Radhakrishnan, Rajeswaran ; Suni, Ian I. ; Bever, Candace S. ; Hammock, Bruce D. / Impedance biosensors : Applications to sustainability and remaining technical challenges. In: ACS Sustainable Chemistry and Engineering. 2014 ; Vol. 2, No. 7. pp. 1649-1655.
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