Impedance biosensors: Applications to sustainability and remaining technical challenges

Rajeswaran Radhakrishnan, Ian I. Suni, Candace S. Bever, Bruce D. Hammock

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Due to their all-electrical nature, impedance biosensors have significant potential for use as simple and portable sensors for environmental studies and environmental monitoring. Detection of two endocrine-disrupting chemicals (EDC), norfluoxetine and BDE-47, is reported here by impedance biosensing, with a detection limit of 8.5 and 1.3 ng/mL for norfluoxetine and BDE-47, respectively. Although impedance biosensors have been widely studied in the academic literature, commercial applications have been hindered by several technical limitations, including possible limitations to small analytes, the complexity of impedance detection, susceptibility to nonspecific adsorption, and stability of biomolecule immobilization. Recent research into methods to overcome these obstacles is briefly reviewed. New results demonstrating antibody regeneration atop degenerate (highly doped) Si are also reported. Using 0.2 M KSCN and 10 mM HF for antibody regeneration, peanut protein Ara h 1 is detected daily during a 30 day trial.

Original languageEnglish (US)
Pages (from-to)1649-1655
Number of pages7
JournalACS Sustainable Chemistry and Engineering
Issue number7
StatePublished - Jul 7 2014


  • Biosensors
  • Electrochemical impedance spectroscopy
  • Endocrine-disrupting chemicals
  • Nanotechnology
  • Sustainability

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)
  • Renewable Energy, Sustainability and the Environment
  • Environmental Chemistry


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