Impairments in precision, rather than spatial strategy, characterize performance on the virtual Morris Water Maze: A case study

Branden S. Kolarik, Kiarash Shahlaie, Abdul Hassan, Alyssa A. Borders, Kyle C. Kaufman, Gene G Gurkoff, Andy P. Yonelinas, Arne D. Ekstrom

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Damage to the medial temporal lobes produces profound amnesia, greatly impairing the ability of patients to learn about new associations and events. While studies in rodents suggest a strong link between damage to the hippocampus and the ability to navigate using distal landmarks in a spatial environment, the connection between navigation and memory in humans remains less clear. Past studies on human navigation have provided mixed findings about whether patients with damage to the medial temporal lobes can successfully acquire and navigate new spatial environments, possibly due, in part, to issues related to patient demographics and characterization of medial temporal lobe damage. Here, we report findings from a young, high functioning patient who suffered severe medial temporal lobe damage. Although the patient is densely amnestic, her ability to acquire and utilize new, but coarse, spatial "maps" appears largely intact. Specifically, a novel computational analysis focused on the precision of her spatial search revealed a significant deficit in spatial precision rather than spatial search strategy. These findings argue that an intact hippocampus in humans is not necessary for representing multiple external landmarks during spatial navigation of new environments. We suggest instead that the human hippocampus may store and represent complex high-resolution bindings of features in the environment as part of a larger role in perception, memory, and navigation.

Original languageEnglish (US)
Pages (from-to)90-101
Number of pages12
JournalNeuropsychologia
Volume80
DOIs
StatePublished - Jan 8 2016

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Temporal Lobe
Aptitude
Water
Hippocampus
Amnesia
Rodentia
Demography

Keywords

  • Allocentric cognitive map
  • Hippocampus
  • Memory
  • Morris Water Maze
  • MTL lesion
  • Spatial memory

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Impairments in precision, rather than spatial strategy, characterize performance on the virtual Morris Water Maze : A case study. / Kolarik, Branden S.; Shahlaie, Kiarash; Hassan, Abdul; Borders, Alyssa A.; Kaufman, Kyle C.; Gurkoff, Gene G; Yonelinas, Andy P.; Ekstrom, Arne D.

In: Neuropsychologia, Vol. 80, 08.01.2016, p. 90-101.

Research output: Contribution to journalArticle

Kolarik, Branden S. ; Shahlaie, Kiarash ; Hassan, Abdul ; Borders, Alyssa A. ; Kaufman, Kyle C. ; Gurkoff, Gene G ; Yonelinas, Andy P. ; Ekstrom, Arne D. / Impairments in precision, rather than spatial strategy, characterize performance on the virtual Morris Water Maze : A case study. In: Neuropsychologia. 2016 ; Vol. 80. pp. 90-101.
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