Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation

Jefferson W. Kinney, Manuel Sanchez-Alavez, Alasdair M. Barr, Jose R. Criado, Jacqueline Crawley, M. Margarita Behrens, Steven J. Henriksen, Tamas Bartfai

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Changes in the state of CREB phosphorylation and in LTP in the hippocampus have been associated with learning and memory. Here we show that galanin, the neuropeptide released in the hippocampal formation from cholinergic and noradrenergic fibers, that has been shown to produce impairments in memory consolidation in the Morris water maze task inhibits both LTP and CREB phosphorylation in the rat hippocampus in vivo. While there are many transmitters regulating CREB phosphorylation none has been shown to suppress behaviorally-induced hippocampal CREB phosphorylation as potently as galanin. The in vivo inhibition of dentate gyrus-LTP and of CREB phosphorylation by the agonist occupancy of GalR1 and GalR2-type galanin receptors provides strong in vivo cellular and molecular correlates to galanin-induced learning deficits and designates galanin as a major regulator of the memory consolidation process.

Original languageEnglish (US)
Pages (from-to)429-438
Number of pages10
JournalNeurobiology of Learning and Memory
Volume92
Issue number3
DOIs
StatePublished - Oct 2009
Externally publishedYes

Fingerprint

Galanin
Phosphorylation
Hippocampus
Galanin Receptors
Cholinergic Fibers
Learning
Dentate Gyrus
Neuropeptides
Inhibition (Psychology)
Memory Consolidation
Water

Keywords

  • Galanin
  • In vivo
  • Learning and memory
  • LTP
  • Morris water maze
  • pCREB

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation. / Kinney, Jefferson W.; Sanchez-Alavez, Manuel; Barr, Alasdair M.; Criado, Jose R.; Crawley, Jacqueline; Behrens, M. Margarita; Henriksen, Steven J.; Bartfai, Tamas.

In: Neurobiology of Learning and Memory, Vol. 92, No. 3, 10.2009, p. 429-438.

Research output: Contribution to journalArticle

Kinney, Jefferson W. ; Sanchez-Alavez, Manuel ; Barr, Alasdair M. ; Criado, Jose R. ; Crawley, Jacqueline ; Behrens, M. Margarita ; Henriksen, Steven J. ; Bartfai, Tamas. / Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation. In: Neurobiology of Learning and Memory. 2009 ; Vol. 92, No. 3. pp. 429-438.
@article{d0c2f3664e844d7db2074664940fe978,
title = "Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation",
abstract = "Changes in the state of CREB phosphorylation and in LTP in the hippocampus have been associated with learning and memory. Here we show that galanin, the neuropeptide released in the hippocampal formation from cholinergic and noradrenergic fibers, that has been shown to produce impairments in memory consolidation in the Morris water maze task inhibits both LTP and CREB phosphorylation in the rat hippocampus in vivo. While there are many transmitters regulating CREB phosphorylation none has been shown to suppress behaviorally-induced hippocampal CREB phosphorylation as potently as galanin. The in vivo inhibition of dentate gyrus-LTP and of CREB phosphorylation by the agonist occupancy of GalR1 and GalR2-type galanin receptors provides strong in vivo cellular and molecular correlates to galanin-induced learning deficits and designates galanin as a major regulator of the memory consolidation process.",
keywords = "Galanin, In vivo, Learning and memory, LTP, Morris water maze, pCREB",
author = "Kinney, {Jefferson W.} and Manuel Sanchez-Alavez and Barr, {Alasdair M.} and Criado, {Jose R.} and Jacqueline Crawley and Behrens, {M. Margarita} and Henriksen, {Steven J.} and Tamas Bartfai",
year = "2009",
month = "10",
doi = "10.1016/j.nlm.2009.06.005",
language = "English (US)",
volume = "92",
pages = "429--438",
journal = "Neurobiology of Learning and Memory",
issn = "1074-7427",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation

AU - Kinney, Jefferson W.

AU - Sanchez-Alavez, Manuel

AU - Barr, Alasdair M.

AU - Criado, Jose R.

AU - Crawley, Jacqueline

AU - Behrens, M. Margarita

AU - Henriksen, Steven J.

AU - Bartfai, Tamas

PY - 2009/10

Y1 - 2009/10

N2 - Changes in the state of CREB phosphorylation and in LTP in the hippocampus have been associated with learning and memory. Here we show that galanin, the neuropeptide released in the hippocampal formation from cholinergic and noradrenergic fibers, that has been shown to produce impairments in memory consolidation in the Morris water maze task inhibits both LTP and CREB phosphorylation in the rat hippocampus in vivo. While there are many transmitters regulating CREB phosphorylation none has been shown to suppress behaviorally-induced hippocampal CREB phosphorylation as potently as galanin. The in vivo inhibition of dentate gyrus-LTP and of CREB phosphorylation by the agonist occupancy of GalR1 and GalR2-type galanin receptors provides strong in vivo cellular and molecular correlates to galanin-induced learning deficits and designates galanin as a major regulator of the memory consolidation process.

AB - Changes in the state of CREB phosphorylation and in LTP in the hippocampus have been associated with learning and memory. Here we show that galanin, the neuropeptide released in the hippocampal formation from cholinergic and noradrenergic fibers, that has been shown to produce impairments in memory consolidation in the Morris water maze task inhibits both LTP and CREB phosphorylation in the rat hippocampus in vivo. While there are many transmitters regulating CREB phosphorylation none has been shown to suppress behaviorally-induced hippocampal CREB phosphorylation as potently as galanin. The in vivo inhibition of dentate gyrus-LTP and of CREB phosphorylation by the agonist occupancy of GalR1 and GalR2-type galanin receptors provides strong in vivo cellular and molecular correlates to galanin-induced learning deficits and designates galanin as a major regulator of the memory consolidation process.

KW - Galanin

KW - In vivo

KW - Learning and memory

KW - LTP

KW - Morris water maze

KW - pCREB

UR - http://www.scopus.com/inward/record.url?scp=69249215121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69249215121&partnerID=8YFLogxK

U2 - 10.1016/j.nlm.2009.06.005

DO - 10.1016/j.nlm.2009.06.005

M3 - Article

C2 - 19531380

AN - SCOPUS:69249215121

VL - 92

SP - 429

EP - 438

JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

SN - 1074-7427

IS - 3

ER -