Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation

Jefferson W. Kinney, Manuel Sanchez-Alavez, Alasdair M. Barr, Jose R. Criado, Jacqueline Crawley, M. Margarita Behrens, Steven J. Henriksen, Tamas Bartfai

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Changes in the state of CREB phosphorylation and in LTP in the hippocampus have been associated with learning and memory. Here we show that galanin, the neuropeptide released in the hippocampal formation from cholinergic and noradrenergic fibers, that has been shown to produce impairments in memory consolidation in the Morris water maze task inhibits both LTP and CREB phosphorylation in the rat hippocampus in vivo. While there are many transmitters regulating CREB phosphorylation none has been shown to suppress behaviorally-induced hippocampal CREB phosphorylation as potently as galanin. The in vivo inhibition of dentate gyrus-LTP and of CREB phosphorylation by the agonist occupancy of GalR1 and GalR2-type galanin receptors provides strong in vivo cellular and molecular correlates to galanin-induced learning deficits and designates galanin as a major regulator of the memory consolidation process.

Original languageEnglish (US)
Pages (from-to)429-438
Number of pages10
JournalNeurobiology of Learning and Memory
Issue number3
StatePublished - Oct 2009
Externally publishedYes


  • Galanin
  • In vivo
  • Learning and memory
  • LTP
  • Morris water maze
  • pCREB

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology


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