Impairment by cyclosporin A of reperfusion-induced arrhythmias

Diana Arteaga, Alberto M Odor, Rosa M. López, Gloria Contreras, Julieta Pichardo, Elizabeth García, Alberto Aranda, Edmundo Chávez

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33 Scopus citations

Abstract

This study introduces the immunosuppressor, cyclosporin A, as a cardioprotective drug. This effect was analyzed during development of reperfusion/induced arrhythmias after 5-min period of coronary ligation in hearts of rats under anesthesia. The results indicate that cyclosporin, when given before coronary occlusion, at a dose of 20 mg/kg, effectively protects against the high incidence of arrhythmias and the fall in blood pressure induced by reperfusion. In addition, it inhibits the delivery of lactic dehydrogenase and creatine kinase enzymes to the plasma. We propose that the protective effect could be related with its well documented action to restrain Ca2+-induced damage of mitochondrial functions.

Original languageEnglish (US)
Pages (from-to)1127-1134
Number of pages8
JournalLife Sciences
Volume51
Issue number14
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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    Arteaga, D., Odor, A. M., López, R. M., Contreras, G., Pichardo, J., García, E., Aranda, A., & Chávez, E. (1992). Impairment by cyclosporin A of reperfusion-induced arrhythmias. Life Sciences, 51(14), 1127-1134. https://doi.org/10.1016/0024-3205(92)90514-P