Impaired spatial information processing in aged monkeys with preserved recognition memory

Peter R. Rapp, Mary T. Kansky, Jeffrey A Roberts

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

SPATIAL information processing was examined in a non-human primate model of cognitive aging, using procedures formally similar to tasks designed for rats. The test apparatus was a large open field containing eight reward locations. Monkeys rapidly learned to visit each location once per trial, and probe manipulations confirmed that young animals navigated according to the distribution of cues surrounding the maze. In contrast, aged monkeys solved the task using a response sequencing strategy, independent of extramaze spatial information. Object recognition memory was normal in the aged group. The results reveal substantial correspondence in the cognitive effects of aging across rat and primate models, and they establish appropriate procedures for testing the long-standing proposal that the role of the hippocampus in normal spatial learning is similarly conserved.

Original languageEnglish (US)
Pages (from-to)1923-1928
Number of pages6
JournalNeuroReport
Volume8
Issue number8
StatePublished - 1997

Keywords

  • Aging
  • Hippocampus
  • Monkey
  • Recognition memory
  • Spatial learning

ASJC Scopus subject areas

  • Neuroscience(all)

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