Impaired Nitric Oxide Synthase Signaling Dissociates Social Investigation and Aggression

Brian C. Trainor, Joanna L. Workman, Ruth Jessen, Randy J. Nelson

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

A combination of social withdrawal and increased aggression is characteristic of several mental disorders. Most previous studies have investigated the neurochemical bases of social behavior and aggression independently, as opposed to how these behaviors are regulated in concert. Neuronal nitric oxide synthase (nNOS) produces gaseous nitric oxide, which functions as a neurotransmitter and is known to affect several types of behavior including mating and aggression. Compared with wild-type mice, we observed that nNOS knockout mice showed reduced behavioral responses to an intruder behind a wire barrier. Similar results were observed in mice treated with the selective nNOS inhibitor 3-bromo-7-nitroindazole (3BrN). In habituation-dishabituation tests, treatment with 3BrN did not block recognition of male urine but did attenuate investigation time compared with oil-treated animals. Finally, nNOS knockout mice and 3BrN treated mice were significantly more aggressive than wild-type and oil-treated males, respectively. In general, these behavioral effects are less pronounced in pair-housed males compared with singly-housed males. Thus, nNOS inhibition results in a phenotype that displays reduced social investigation and increased aggression. These data suggest that further study of nNOS signaling is warranted in mental disorders characterized by social withdrawal and increased aggression.

Original languageEnglish (US)
Pages (from-to)362-369
Number of pages8
JournalBehavioral Neuroscience
Volume121
Issue number2
DOIs
StatePublished - Apr 2007
Externally publishedYes

Fingerprint

Nitric Oxide Synthase Type I
Aggression
Nitric Oxide Synthase
Mental Disorders
Knockout Mice
Oils
Social Behavior
Neurotransmitter Agents
Nitric Oxide
Urine
Phenotype
3-bromo-7-nitroindazole

Keywords

  • aggression
  • autism
  • nitric oxide synthase
  • serotonin
  • social investigation

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Impaired Nitric Oxide Synthase Signaling Dissociates Social Investigation and Aggression. / Trainor, Brian C.; Workman, Joanna L.; Jessen, Ruth; Nelson, Randy J.

In: Behavioral Neuroscience, Vol. 121, No. 2, 04.2007, p. 362-369.

Research output: Contribution to journalArticle

Trainor, Brian C. ; Workman, Joanna L. ; Jessen, Ruth ; Nelson, Randy J. / Impaired Nitric Oxide Synthase Signaling Dissociates Social Investigation and Aggression. In: Behavioral Neuroscience. 2007 ; Vol. 121, No. 2. pp. 362-369.
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