Impaired multiple object tracking in children with chromosome 22q11.2 deletion syndrome

Margarita H. Cabaral, Elliott A. Beaton, Joel Stoddard, Tony J Simon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Chromosome 22q11.2 Deletion Syndrome (22q11.2DS) occurs in approximately 1:4,000 live births with a complex and variable presentation that includes medical, socioemotional and psychological symptoms with intellectual impairment. Cognitive impairments in spatiotemporal and visuospatial attention have also been reported. However, maintenance of selective attention to dynamic and interacting objects has not been systematically investigated in children with 22q11.2DS. Methods: We used a multiple object tracking task to assay capacity and resolution performance of children with 22q11.2DS aged 7 to 14 years versus age-matched typically developing (TD) peers. Results: Children with 22q11.2DS but not TD children demonstrated impaired performance when task demands increased due to an increase in the number of targets presented, but not from an increase in object speed. Task performance in children with 22q11.2DS was also unrelated to intelligence or measures of attention deficit hyperactivity disorder. Conclusions: These findings suggest that children with 22q11.2DS may be particularly susceptible to dynamic crowding of objects with increasing cognitive demands related to monitoring multiple targets reflecting a reduced acuity in spatiotemporal cognitive representation.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Neurodevelopmental Disorders
Volume4
Issue number1
DOIs
StatePublished - 2012

Fingerprint

DiGeorge Syndrome
Chromosome Deletion
Task Performance and Analysis
Crowding
Live Birth
Attention Deficit Disorder with Hyperactivity
Intelligence
Maintenance
Psychology

Keywords

  • Attention
  • Children
  • Chromosome 22q11.2 deletion syndrome (22q11.2ds)
  • Digeorge syndrome
  • Multiple object tracking
  • Spatiotemporal attention
  • Velocardiofacial syndrome (VCFS)

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cognitive Neuroscience
  • Pediatrics, Perinatology, and Child Health

Cite this

Impaired multiple object tracking in children with chromosome 22q11.2 deletion syndrome. / Cabaral, Margarita H.; Beaton, Elliott A.; Stoddard, Joel; Simon, Tony J.

In: Journal of Neurodevelopmental Disorders, Vol. 4, No. 1, 2012, p. 1-8.

Research output: Contribution to journalArticle

Cabaral, Margarita H. ; Beaton, Elliott A. ; Stoddard, Joel ; Simon, Tony J. / Impaired multiple object tracking in children with chromosome 22q11.2 deletion syndrome. In: Journal of Neurodevelopmental Disorders. 2012 ; Vol. 4, No. 1. pp. 1-8.
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