Impaired development of T lymphoid precursors from pluripotent hematopoietic stem cells in New Zealand Black mice

Y. Hashimoto, E. Montecino-Rodriguez, M. Eric Gershwin, K. Dorshkind

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Bone marrow cells from autoimmune-prone New Zealand Black (NZB) mice are less efficient at colonizing fetal thymic lobes than cells from normal strains. This study demonstrates that the reduced capacity of NZB bone marrow cells to repopulate the thymus does not result from their inability to migrate to or enter the thymus. Rather, the T lymphopoietic defect of NZB mice is due to an impaired ability of pluripotent hematopoietic stem cells (PHSCs) to generate more committed lymphoid progeny, which could include common lymphoid precursors and/or other T cell-committed progenitors. Although PHSCs from NZB mice were not as efficient at thymic repopulation as comparable numbers of PHSCs from control strains, the ability of common lymphoid precursors from NZB mice to repopulate the thymus was not defective. Similarly, more differentiated NZB T cell precursors included in the intrathymic pool of CD4-CD8- cells also exhibited normal T lymphopoietic potential. Taken together, the results identify an unappreciated defect in NZB mice and provide further evidence that generation of lymphoid progeny from the PHSCs is a regulated event.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalJournal of Immunology
Volume168
Issue number1
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Immunology

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