Impaired context processing as a potential marker of psychosis risk state

Tara A Niendam; Tyler A. Lesh; Jong Yoon; Andrew J. Westphal; Natalie Hutchison; John D Ragland; Marjorie Solomon Friedman; Michael Minzenberg; Cameron S Carter

doi:10.1016/j.pscychresns.2013.09.001

Impaired context processing as a potential marker of psychosis risk state

Tara A Niendam, Tyler A. Lesh, Jong Yoon, Andrew J. Westphal, Natalie Hutchison, John D Ragland, Marjorie Solomon Friedman, Michael Minzenberg, Cameron S Carter

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis.

Original language	English (US)
Pages (from-to)	13-20
Number of pages	8
Journal	Psychiatry Research - Neuroimaging
Volume	221
Issue number	1
DOIs	https://doi.org/10.1016/j.pscychresns.2013.09.001
State	Published - Jan 30 2014

Keywords

Clinical high risk
Cognition
FMRI
Prefrontal cortex
Psychosis
Ultra high risk

ASJC Scopus subject areas

Psychiatry and Mental health
Radiology Nuclear Medicine and imaging
Neuroscience (miscellaneous)

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Impaired context processing as a potential marker of psychosis risk state. / Niendam, Tara A; Lesh, Tyler A.; Yoon, Jong; Westphal, Andrew J.; Hutchison, Natalie; Ragland, John D ; Friedman, Marjorie Solomon; Minzenberg, Michael; Carter, Cameron S.

In: Psychiatry Research - Neuroimaging, Vol. 221, No. 1, 30.01.2014, p. 13-20.

Research output: Contribution to journal › Article › peer-review

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