Impact of thermal processing on trace element status of formula fed infant rhesus monkeys

B. Lönnerdal, S. Kelleher, S. M. Kaup, E. Lien

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The infant rhesus monkey is an excellent animal model for studying the effect of various infant formulas on trace element absorption and status. Infant monkeys fed regular, powdered infant formula exclusively from birth to 6 mo of age exhibit normal growth and have blood parameters similar to those of breast-fed monkeys. Moreover, breast-fed monkeys and monkeys fed formula with different levels of iron have hematological indices similar to those of human infants. In this study, we explored the effect of feeding infant monkeys different whey-dominant ready-to-feed formulas: Formula in cans at 12 mg Fe/L available in U.S. (C), and formula in glass bottles: UHT process (12 mg Fe/L) and standard thermal process (STP) at either 8 (STP8) or 12 mg Fe/L (STP 12). Growth and indices of Fe status, (hemoglobin, MCV and serum ferritin) were similar in all groups. However, infants fed can-formula showed a progressive and significant decline in serum Cu [5 mo C:0.44±0.02; UHT:1.32±0.19; STP8:0.94±0.17; STP 12:0.73±0.18 mg/L] and RBC Cu, Zn-superoxide dismutase activity during the 5 mo study. Moreover, coat color changed dramatically from the normal brown to a silvery-white color. UHT and STP fed monkeys did not exhibit changes in Cu status or coat color. These data suggest that formula processing conditions affect Cu status.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

Infant Formula
Trace Elements
infant formulas
Macaca mulatta
Haplorhini
monkeys
trace elements
Hot Temperature
heat treatment
Color
heat
feed formulation
Glass bottles
blood serum
cans
breasts
color
Breast
Ferritins
infant feeding

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Lönnerdal, B., Kelleher, S., Kaup, S. M., & Lien, E. (1997). Impact of thermal processing on trace element status of formula fed infant rhesus monkeys. FASEB Journal, 11(3).

Impact of thermal processing on trace element status of formula fed infant rhesus monkeys. / Lönnerdal, B.; Kelleher, S.; Kaup, S. M.; Lien, E.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Lönnerdal, B, Kelleher, S, Kaup, SM & Lien, E 1997, 'Impact of thermal processing on trace element status of formula fed infant rhesus monkeys', FASEB Journal, vol. 11, no. 3.
Lönnerdal, B. ; Kelleher, S. ; Kaup, S. M. ; Lien, E. / Impact of thermal processing on trace element status of formula fed infant rhesus monkeys. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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