Impact of the blood sampling site on time-concentration drug profiles following intravenous or buccal drug administration

A. R. Hedges, Bruno H Pypendop, Y. Shilo, Scott D Stanley, Jan Ilkiw

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The aim of this study was to examine the effect of the sampling site on the drug concentration-time profile, following intravenous or buccal (often called 'oral transmucosal') drug administration. Buprenorphine (20 μg/kg) was administered IV or buccally to six cats. Blood samples were collected from the carotid artery and the jugular and medial saphenous veins for 24 h following buprenorphine administration. Buprenorphine concentration-time data were examined using noncompartmental analysis. Pharmacokinetic parameters were compared using the Wilcoxon signed rank test, applying the Bonferroni correction. Significance was set at P < 0.05. Following IV administration, no difference among the sampling sites was found. Following buccal administration, maximum concentration [jugular: 6.3 (2.9-9.8), carotid: 3.4 (1.9-4.9), medial saphenous: 2.5 (1.7-4.1) ng/mL], area under the curve [jugular: 395 (335-747), carotid: 278 (214-693), medial saphenous: 255 (188-608) ng·min/mL], and bioavailability [jugular: 47 (34-67), carotid: 32 (20-52), medial saphenous: 23 (16-55)%] were higher in the jugular vein than in the carotid artery and medial saphenous vein. Jugular venous blood sampling is not an acceptable substitute for arterial blood sampling following buccal drug administration.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume37
Issue number2
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Fingerprint Dive into the research topics of 'Impact of the blood sampling site on time-concentration drug profiles following intravenous or buccal drug administration'. Together they form a unique fingerprint.

  • Cite this