Impact of Telomere Shortening with Age in Stem Cell Therapy: New Strategies to Increase Telomere Length

Nathalie Nguyen; Nirmala Hariharan; Mark A. Sussman

doi:10.1016/B978-0-12-801888-0.00005-9

Impact of Telomere Shortening with Age in Stem Cell Therapy: New Strategies to Increase Telomere Length

Nathalie Nguyen, Nirmala Hariharan, Mark A. Sussman

Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Adult stem cell functionality is impaired upon aging. This impedes on the success of stem cell-based regenerative therapy in aged individuals suffering from heart failure, which represent the target population for regenerative medicine. Therefore, a better understanding of the underlying mechanisms involved in cellular aging is essential in order to provide a more efficient therapeutic strategy. Accumulation of cellular damage occurs with age. Consequently, a constant cell turnover takes place in order to replace damaged cells leading to telomere attrition. Telomere shortening is thus a critical factor in cellular aging. Strategies focusing on preserving or elongating telomere length represent an attractive approach for the rejuvenation of stem cells. This chapter highlights the impact of aging on telomere length in stem cells and suggests new strategies to improve stem cell properties by maintaining telomere length.

Original language	English (US)
Title of host publication	Stem Cell and Gene Therapy for Cardiovascular Disease
Publisher	Elsevier Science Ltd.
Pages	49-58
Number of pages	10
ISBN (Electronic)	9780128018637
ISBN (Print)	9780128018880
DOIs	https://doi.org/10.1016/B978-0-12-801888-0.00005-9
State	Published - Jan 1 2015

Keywords

Aging
Cardiac stem cell
Senescence
Stem cell
Telomerase
Telomere

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-801888-0.00005-9

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abstract = "Adult stem cell functionality is impaired upon aging. This impedes on the success of stem cell-based regenerative therapy in aged individuals suffering from heart failure, which represent the target population for regenerative medicine. Therefore, a better understanding of the underlying mechanisms involved in cellular aging is essential in order to provide a more efficient therapeutic strategy. Accumulation of cellular damage occurs with age. Consequently, a constant cell turnover takes place in order to replace damaged cells leading to telomere attrition. Telomere shortening is thus a critical factor in cellular aging. Strategies focusing on preserving or elongating telomere length represent an attractive approach for the rejuvenation of stem cells. This chapter highlights the impact of aging on telomere length in stem cells and suggests new strategies to improve stem cell properties by maintaining telomere length.",

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