Impact of point spread function reconstruction on quantitative 18F-FDG-PET/CT imaging parameters and inter-reader reproducibility in solid tumors

Sara Sheikhbahaei, Charles Marcus, Rick Arthur Wray, Arman Rahmim, Martin A. Lodge, Rathan M. Subramaniam

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Introduction This study aims to determine the impact of point-spread function (PSF) reconstruction on quantitative PET/computed tomography (CT) indices and the inter-reader reproducibility of these measurements. Materials and methods The study was approved by the Institutional Review Board under a waiver of informed consent. A total of 42 oncology patients with 85 lesions (all ≥2 cm) were included. The PET/CT images were reconstructed with PSF (OSEM+TOF, 2i, 21s, all-pass filter) and without PSF (OSEM+TOF, 2i, 21s, 5 mm Gaussian). For each lesion, the maximum, mean, and peak standardized uptake values (SUV), total lesion glycolysis (TLG), and metabolic tumor volume (MTV) were measured by two readers (R1 and R2) using a semiautomatic gradient segmentation method. Intraclass correlation coefficient (ICC) and Bland-Altman analyses were performed. Results There was excellent correlation between non-PSF and PSF reconstruction PET/CT values (ICC≥0.96 for all parameters, P<0.0001). Comparison of PSF with non-PSF images showed a mean bias (percentage change) of +11.97% (R1) and +11.94% (R2) for SUV max, +7.63% (R1) and +7.82% (R2) for SUV mean, +7.45% (R1) and +7.37% (R2) for SUV peak,-0.82% (R1) and-0.1% (R2) for TLG, and-6.68% (R1) and-5.65% (R2) for MTV. PSF reconstruction resulted in a decrease in MTV in 77.6% (R1) and 83.5% (R2) of lesions. Percentage changes in PSF versus non-PSF indices were not related to the site of the lesions (P>0.05). Close agreement was observed between two readers (ICC ranged between 0.9 and 1.0, P<0.0001). Conclusion The PSF reconstruction increased the SUV max, SUV mean, and SUV peak, as expected, whereas it tended to produce lower values for MTV and had variable effect on TLG. This can be attributed to the ability of PSF reconstruction to better discern tumor uptake from activity spill-out.

Original languageEnglish (US)
Pages (from-to)288-296
Number of pages9
JournalNuclear Medicine Communications
Volume37
Issue number3
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Fingerprint

Fluorodeoxyglucose F18
Tomography
Glycolysis
Tumor Burden
Neoplasms
Research Ethics Committees
Informed Consent

Keywords

  • F-FDG
  • image processing
  • oncology
  • PET
  • point-spread function reconstruction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Impact of point spread function reconstruction on quantitative 18F-FDG-PET/CT imaging parameters and inter-reader reproducibility in solid tumors. / Sheikhbahaei, Sara; Marcus, Charles; Wray, Rick Arthur; Rahmim, Arman; Lodge, Martin A.; Subramaniam, Rathan M.

In: Nuclear Medicine Communications, Vol. 37, No. 3, 01.07.2016, p. 288-296.

Research output: Contribution to journalArticle

Sheikhbahaei, Sara ; Marcus, Charles ; Wray, Rick Arthur ; Rahmim, Arman ; Lodge, Martin A. ; Subramaniam, Rathan M. / Impact of point spread function reconstruction on quantitative 18F-FDG-PET/CT imaging parameters and inter-reader reproducibility in solid tumors. In: Nuclear Medicine Communications. 2016 ; Vol. 37, No. 3. pp. 288-296.
@article{e1ef4979322643f9b1065d0c3a5afbb9,
title = "Impact of point spread function reconstruction on quantitative 18F-FDG-PET/CT imaging parameters and inter-reader reproducibility in solid tumors",
abstract = "Introduction This study aims to determine the impact of point-spread function (PSF) reconstruction on quantitative PET/computed tomography (CT) indices and the inter-reader reproducibility of these measurements. Materials and methods The study was approved by the Institutional Review Board under a waiver of informed consent. A total of 42 oncology patients with 85 lesions (all ≥2 cm) were included. The PET/CT images were reconstructed with PSF (OSEM+TOF, 2i, 21s, all-pass filter) and without PSF (OSEM+TOF, 2i, 21s, 5 mm Gaussian). For each lesion, the maximum, mean, and peak standardized uptake values (SUV), total lesion glycolysis (TLG), and metabolic tumor volume (MTV) were measured by two readers (R1 and R2) using a semiautomatic gradient segmentation method. Intraclass correlation coefficient (ICC) and Bland-Altman analyses were performed. Results There was excellent correlation between non-PSF and PSF reconstruction PET/CT values (ICC≥0.96 for all parameters, P<0.0001). Comparison of PSF with non-PSF images showed a mean bias (percentage change) of +11.97{\%} (R1) and +11.94{\%} (R2) for SUV max, +7.63{\%} (R1) and +7.82{\%} (R2) for SUV mean, +7.45{\%} (R1) and +7.37{\%} (R2) for SUV peak,-0.82{\%} (R1) and-0.1{\%} (R2) for TLG, and-6.68{\%} (R1) and-5.65{\%} (R2) for MTV. PSF reconstruction resulted in a decrease in MTV in 77.6{\%} (R1) and 83.5{\%} (R2) of lesions. Percentage changes in PSF versus non-PSF indices were not related to the site of the lesions (P>0.05). Close agreement was observed between two readers (ICC ranged between 0.9 and 1.0, P<0.0001). Conclusion The PSF reconstruction increased the SUV max, SUV mean, and SUV peak, as expected, whereas it tended to produce lower values for MTV and had variable effect on TLG. This can be attributed to the ability of PSF reconstruction to better discern tumor uptake from activity spill-out.",
keywords = "F-FDG, image processing, oncology, PET, point-spread function reconstruction",
author = "Sara Sheikhbahaei and Charles Marcus and Wray, {Rick Arthur} and Arman Rahmim and Lodge, {Martin A.} and Subramaniam, {Rathan M.}",
year = "2016",
month = "7",
day = "1",
doi = "10.1097/MNM.0000000000000445",
language = "English (US)",
volume = "37",
pages = "288--296",
journal = "Nuclear Medicine Communications",
issn = "0143-3636",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Impact of point spread function reconstruction on quantitative 18F-FDG-PET/CT imaging parameters and inter-reader reproducibility in solid tumors

AU - Sheikhbahaei, Sara

AU - Marcus, Charles

AU - Wray, Rick Arthur

AU - Rahmim, Arman

AU - Lodge, Martin A.

AU - Subramaniam, Rathan M.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Introduction This study aims to determine the impact of point-spread function (PSF) reconstruction on quantitative PET/computed tomography (CT) indices and the inter-reader reproducibility of these measurements. Materials and methods The study was approved by the Institutional Review Board under a waiver of informed consent. A total of 42 oncology patients with 85 lesions (all ≥2 cm) were included. The PET/CT images were reconstructed with PSF (OSEM+TOF, 2i, 21s, all-pass filter) and without PSF (OSEM+TOF, 2i, 21s, 5 mm Gaussian). For each lesion, the maximum, mean, and peak standardized uptake values (SUV), total lesion glycolysis (TLG), and metabolic tumor volume (MTV) were measured by two readers (R1 and R2) using a semiautomatic gradient segmentation method. Intraclass correlation coefficient (ICC) and Bland-Altman analyses were performed. Results There was excellent correlation between non-PSF and PSF reconstruction PET/CT values (ICC≥0.96 for all parameters, P<0.0001). Comparison of PSF with non-PSF images showed a mean bias (percentage change) of +11.97% (R1) and +11.94% (R2) for SUV max, +7.63% (R1) and +7.82% (R2) for SUV mean, +7.45% (R1) and +7.37% (R2) for SUV peak,-0.82% (R1) and-0.1% (R2) for TLG, and-6.68% (R1) and-5.65% (R2) for MTV. PSF reconstruction resulted in a decrease in MTV in 77.6% (R1) and 83.5% (R2) of lesions. Percentage changes in PSF versus non-PSF indices were not related to the site of the lesions (P>0.05). Close agreement was observed between two readers (ICC ranged between 0.9 and 1.0, P<0.0001). Conclusion The PSF reconstruction increased the SUV max, SUV mean, and SUV peak, as expected, whereas it tended to produce lower values for MTV and had variable effect on TLG. This can be attributed to the ability of PSF reconstruction to better discern tumor uptake from activity spill-out.

AB - Introduction This study aims to determine the impact of point-spread function (PSF) reconstruction on quantitative PET/computed tomography (CT) indices and the inter-reader reproducibility of these measurements. Materials and methods The study was approved by the Institutional Review Board under a waiver of informed consent. A total of 42 oncology patients with 85 lesions (all ≥2 cm) were included. The PET/CT images were reconstructed with PSF (OSEM+TOF, 2i, 21s, all-pass filter) and without PSF (OSEM+TOF, 2i, 21s, 5 mm Gaussian). For each lesion, the maximum, mean, and peak standardized uptake values (SUV), total lesion glycolysis (TLG), and metabolic tumor volume (MTV) were measured by two readers (R1 and R2) using a semiautomatic gradient segmentation method. Intraclass correlation coefficient (ICC) and Bland-Altman analyses were performed. Results There was excellent correlation between non-PSF and PSF reconstruction PET/CT values (ICC≥0.96 for all parameters, P<0.0001). Comparison of PSF with non-PSF images showed a mean bias (percentage change) of +11.97% (R1) and +11.94% (R2) for SUV max, +7.63% (R1) and +7.82% (R2) for SUV mean, +7.45% (R1) and +7.37% (R2) for SUV peak,-0.82% (R1) and-0.1% (R2) for TLG, and-6.68% (R1) and-5.65% (R2) for MTV. PSF reconstruction resulted in a decrease in MTV in 77.6% (R1) and 83.5% (R2) of lesions. Percentage changes in PSF versus non-PSF indices were not related to the site of the lesions (P>0.05). Close agreement was observed between two readers (ICC ranged between 0.9 and 1.0, P<0.0001). Conclusion The PSF reconstruction increased the SUV max, SUV mean, and SUV peak, as expected, whereas it tended to produce lower values for MTV and had variable effect on TLG. This can be attributed to the ability of PSF reconstruction to better discern tumor uptake from activity spill-out.

KW - F-FDG

KW - image processing

KW - oncology

KW - PET

KW - point-spread function reconstruction

UR - http://www.scopus.com/inward/record.url?scp=84949575690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949575690&partnerID=8YFLogxK

U2 - 10.1097/MNM.0000000000000445

DO - 10.1097/MNM.0000000000000445

M3 - Article

C2 - 26650959

AN - SCOPUS:84949575690

VL - 37

SP - 288

EP - 296

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

IS - 3

ER -