Impact of oscillatory tDCS targeting left prefrontal cortex on source memory retrieval

Eda Mizrak, Kamin Kim, Brooke Roberts, Daniel John Ragland, Cameron S Carter, Charan Ranganath

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Research on transcranial direct current stimulation (tDCS) has grown rapidly, but there is controversy regarding whether and how tDCS could impact memory performance. We report a study that addressed this question by examining the effects of oscillatory tDCS (otDCS) on subsequent episodic memory performance and concomitant recordings of neural oscillations. Neural oscillations in the theta band (4–7 Hz) have been shown to be important for episodic memory and especially for source memory retrieval. Here, we tested the effects of anodal otDCS at theta (5.5 Hz) over the left DLPFC on theta oscillations and memory performance. In two sessions, participants completed an item and source recognition paradigm with word stimuli. Between study and test, participants received otDCS in one session and sham stimulation in the other. Surprisingly, behavioral results showed that, relative to the sham stimulation, otDCS impaired source memory performance. Analyses of EEG data during memory retrieval revealed that otDCS changed pre-stimulus theta power and in particular reduced the specificity of theta activity during source memory retrieval. Our results suggest that non-invasive brain stimulation can impact memory and oscillatory activity in counterintuitive ways, and that direct neural activity measures can facilitate meaningful interpretation of behavioral effects of stimulation.

Original languageEnglish (US)
Pages (from-to)194-207
Number of pages14
JournalCognitive Neuroscience
Volume9
Issue number3-4
DOIs
StatePublished - Oct 2 2018

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Prefrontal Cortex
Episodic Memory
Transcranial Direct Current Stimulation
Electroencephalography
Brain
Research

Keywords

  • brain stimulation
  • Episodic memory
  • neural oscillations

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Impact of oscillatory tDCS targeting left prefrontal cortex on source memory retrieval. / Mizrak, Eda; Kim, Kamin; Roberts, Brooke; Ragland, Daniel John; Carter, Cameron S; Ranganath, Charan.

In: Cognitive Neuroscience, Vol. 9, No. 3-4, 02.10.2018, p. 194-207.

Research output: Contribution to journalArticle

Mizrak, Eda ; Kim, Kamin ; Roberts, Brooke ; Ragland, Daniel John ; Carter, Cameron S ; Ranganath, Charan. / Impact of oscillatory tDCS targeting left prefrontal cortex on source memory retrieval. In: Cognitive Neuroscience. 2018 ; Vol. 9, No. 3-4. pp. 194-207.
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