Impact of histologic subtype on cancer-specific survival in patients with renal cell carcinoma and tumor thrombus

Derya Tilki, Hao G. Nguyen, Marc Dall'Era, Roberto Bertini, Joaquín A. Carballido, Thomas Chromecki, Gaetano Ciancio, Siamak Daneshmand, Paolo Gontero, Javier Gonzalez, Axel Haferkamp, Markus Hohenfellner, William C. Huang, Theresa M. Koppie, C. Adam Lorentz, Philipp Mandel, Juan I. Martinez-Salamanca, Viraj A. Master, Rayan Matloob, James M. McKiernanCarrie M. Mlynarczyk, Francesco Montorsi, Giacomo Novara, Sascha Pahernik, Juan Palou, Raj S. Pruthi, Krishna Ramaswamy, Oscar Rodriguez Faba, Paul Russo, Shahrokh F. Shariat, Martin Spahn, Carlo Terrone, Daniel Vergho, Eric M. Wallen, Evanguelos Xylinas, Richard Zigeuner, John A. Libertino, Christopher P Evans

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48 Scopus citations

Abstract

Background Although different prognostic factors for patients with renal cell carcinoma (RCC) and vena cava tumor thrombus (TT) have been studied, the prognostic value of histologic subtype in these patients remains unclear. Objective We analyzed the impact of histologic subtype on cancer-specific survival (CSS). Design, settings, and participants We retrospectively analyzed the records of 1774 patients with RCC and TT who underwent radical nephrectomy and tumor thrombectomy from 1971 to 2012 at 22 US and European centers. Outcome measurements and statistical analysis Multivariable ordered logistic and Cox regression models were used to quantify the impact of tumor histology on CSS. Results and limitations Overall 5-yr CSS was 53.4% (confidence interval [CI], 50.5-56.2) in the entire group. TT level (according to the Mayo classification of macroscopic venous invasion in RCC) was I in 38.5% of patients, II in 30.6%, III in 17.3%, and IV in 13.5%. Histologic subtypes were clear cell renal cell carcinoma (cRCC) in 89.9% of patients, papillary renal cell carcinoma (pRCC) in 8.5%, and chromophobe RCC in 1.6%. In univariable analysis, pRCC was associated with a significantly worse CSS (p < 0.001) compared with cRCC. In multivariable analysis, the presence of pRCC was independently associated with CSS (hazard ratio: 1.62; CI, 1.01-2.61; p < 0.05). Higher TT level, positive lymph node status, distant metastasis, and fat invasion were also independently associated with CSS. Conclusions In our multi-institutional series, we found that patients with pRCC and vena cava TT who underwent radical nephrectomy and tumor thrombectomy had significantly worse cancer-specific outcomes when compared with patients with other histologic subtypes of RCC. We confirmed that higher TT level and fat invasion were independently associated with reduced CSS.

Original languageEnglish (US)
Pages (from-to)577-583
Number of pages7
JournalEuropean Urology
Volume66
Issue number3
DOIs
StatePublished - 2014

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Keywords

  • Clear cell
  • Histology
  • Papillary
  • Prognosis
  • Renal cell carcinoma
  • Survival
  • Vena cava tumor thrombus

ASJC Scopus subject areas

  • Urology

Cite this

Tilki, D., Nguyen, H. G., Dall'Era, M., Bertini, R., Carballido, J. A., Chromecki, T., Ciancio, G., Daneshmand, S., Gontero, P., Gonzalez, J., Haferkamp, A., Hohenfellner, M., Huang, W. C., Koppie, T. M., Lorentz, C. A., Mandel, P., Martinez-Salamanca, J. I., Master, V. A., Matloob, R., ... Evans, C. P. (2014). Impact of histologic subtype on cancer-specific survival in patients with renal cell carcinoma and tumor thrombus. European Urology, 66(3), 577-583. https://doi.org/10.1016/j.eururo.2013.06.048