Impact of DTI smoothing on the study of brain aging

Varsha Viswanath, Evan Fletcher, Baljeet Singh, Noel Smith, Debashis Paul, Jie Peng, Jun Chen, Owen Carmichael

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Diffusion tensor magnetic resonance imaging (DTI), a method for measuring the integrity of axon fiber tracts in the brain, plays an important role in clarifying brain changes that accompany aging and aging-associated neurodegenerative disease. While DTI smoothing methods theoretically have the potential to enhance such studies by reducing noise, it is unclear whether DTI smoothing has any practical impact on computed associations between fiber tract integrity and scientific variables of interest. Therefore we smoothed DTI images from 154 older adults using three kernel smoothing methods hypothesized to have differing strengths (the affine and log-Euclidean smoothers were hypothesized to enhance highly organized tracts better than the Euclidean smoother). Smoothing increased the strengths of expected associations between DTI and age, cognitive function, and the diagnosis of dementia. However, no particular smoothing method was uniformly superior in strengthening these associations. This data suggests that DTI smoothing enhances the sensitivity of studies of brain aging, but further research is needed to determine which smoothing technique is optimal.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages94-97
Number of pages4
DOIs
StatePublished - 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Other

Other34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period8/28/129/1/12

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

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  • Cite this

    Viswanath, V., Fletcher, E., Singh, B., Smith, N., Paul, D., Peng, J., Chen, J., & Carmichael, O. (2012). Impact of DTI smoothing on the study of brain aging. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 94-97). [6345879] https://doi.org/10.1109/EMBC.2012.6345879