Impact of aging in cancer immunotherapy: The importance of using accurate preclinical models

Myriam N. Bouchlaka, William J Murphy

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Cancer immunotherapy holds great promise, yet its efficacy and applicability can be hampered by the rise of systemic toxicities. We have recently shown that the lethal side effects of cancer immunotherapy are markedly exacerbated with aging. Blocking tumor necrosis factor α or macrophages can alleviate the systemic toxicity of immunotherapy while preserving its antineoplastic effects.

Original languageEnglish (US)
Article numbere27186
JournalOncoImmunology
Volume2
Issue number12
DOIs
StatePublished - 2013

Keywords

  • Aging
  • Cancer immunotherapy
  • Inflammation
  • Macrophage
  • Organ damage
  • Pro-inflammatory cytokines
  • TNFα

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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