Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction

Alex Ardans, A. Trommershausen-Smith, Bennie Osburn, I. G. Mayhew, C. Trees, M. I. Park, M. Sawyer, G. H. Stabenfeldt

Research output: Contribution to journal › Article

15 Citations (Scopus)

Abstract

Combined immunodeficiency (CID) in Arabian foals appears to be similar to CID in children. The disease is characterized by a deficiency of T and B lymphocytes. Immunotherapy was attempted in 2 Arabian foals with combined immunodeficiency. One foal was given a transplant of bone marrow from a selected full sibling, and 1 foal was given a fetal thymus transplant. Both foals died. Genetic evidence was obtained for survival of the transplanted tissues in both cases; however, a graft versus host reaction developed in the foal given the fetal thymus transplant.

Original languageEnglish (US)
Pages (from-to)167-175
Number of pages9
JournalJournal of the American Veterinary Medical Association
Volume170
Issue number2
StatePublished - Oct 3 1977

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graft versus host reactions
immunotherapy
immunosuppression
foals
Immunotherapy
Transplants
Arabian (horse breed)
Thymus Gland
Tissue Survival
Siblings
bone marrow transplant
B-Lymphocytes
Bone Marrow
T-Lymphocytes
B-lymphocytes
T-lymphocytes

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Ardans, A., Trommershausen-Smith, A., Osburn, B., Mayhew, I. G., Trees, C., Park, M. I., ... Stabenfeldt, G. H. (1977). Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction. Journal of the American Veterinary Medical Association, 170(2), 167-175.

Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction. / Ardans, Alex; Trommershausen-Smith, A.; Osburn, Bennie; Mayhew, I. G.; Trees, C.; Park, M. I.; Sawyer, M.; Stabenfeldt, G. H.

In: Journal of the American Veterinary Medical Association, Vol. 170, No. 2, 03.10.1977, p. 167-175.

Research output: Contribution to journal › Article

Ardans, A, Trommershausen-Smith, A, Osburn, B, Mayhew, IG, Trees, C, Park, MI, Sawyer, M & Stabenfeldt, GH 1977, 'Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction', Journal of the American Veterinary Medical Association, vol. 170, no. 2, pp. 167-175.
Ardans A, Trommershausen-Smith A, Osburn B, Mayhew IG, Trees C, Park MI et al. Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction. Journal of the American Veterinary Medical Association. 1977 Oct 3;170(2):167-175.
Ardans, Alex ; Trommershausen-Smith, A. ; Osburn, Bennie ; Mayhew, I. G. ; Trees, C. ; Park, M. I. ; Sawyer, M. ; Stabenfeldt, G. H. / Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction. In: Journal of the American Veterinary Medical Association. 1977 ; Vol. 170, No. 2. pp. 167-175.
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