Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction

Alex Ardans; A. Trommershausen-Smith; Bennie Osburn; I. G. Mayhew; C. Trees; M. I. Park; M. Sawyer; G. H. Stabenfeldt

Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction

Alex Ardans, A. Trommershausen-Smith, Bennie Osburn, I. G. Mayhew, C. Trees, M. I. Park, M. Sawyer, G. H. Stabenfeldt

Research output: Contribution to journal › Article › peer-review

Abstract

Combined immunodeficiency (CID) in Arabian foals appears to be similar to CID in children. The disease is characterized by a deficiency of T and B lymphocytes. Immunotherapy was attempted in 2 Arabian foals with combined immunodeficiency. One foal was given a transplant of bone marrow from a selected full sibling, and 1 foal was given a fetal thymus transplant. Both foals died. Genetic evidence was obtained for survival of the transplanted tissues in both cases; however, a graft versus host reaction developed in the foal given the fetal thymus transplant.

Original language	English (US)
Pages (from-to)	167-175
Number of pages	9
Journal	Journal of the American Veterinary Medical Association
Volume	170
Issue number	2
State	Published - Oct 3 1977

ASJC Scopus subject areas

veterinary(all)

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Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction. / Ardans, Alex; Trommershausen-Smith, A.; Osburn, Bennie; Mayhew, I. G.; Trees, C.; Park, M. I.; Sawyer, M.; Stabenfeldt, G. H.

In: Journal of the American Veterinary Medical Association, Vol. 170, No. 2, 03.10.1977, p. 167-175.

Research output: Contribution to journal › Article › peer-review

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AU - Trommershausen-Smith, A.

AU - Osburn, Bennie

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AU - Trees, C.

AU - Park, M. I.

AU - Sawyer, M.

AU - Stabenfeldt, G. H.

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AB - Combined immunodeficiency (CID) in Arabian foals appears to be similar to CID in children. The disease is characterized by a deficiency of T and B lymphocytes. Immunotherapy was attempted in 2 Arabian foals with combined immunodeficiency. One foal was given a transplant of bone marrow from a selected full sibling, and 1 foal was given a fetal thymus transplant. Both foals died. Genetic evidence was obtained for survival of the transplanted tissues in both cases; however, a graft versus host reaction developed in the foal given the fetal thymus transplant.

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