Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction

Alex Ardans, A. Trommershausen-Smith, Bennie Osburn, I. G. Mayhew, C. Trees, M. I. Park, M. Sawyer, G. H. Stabenfeldt

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Combined immunodeficiency (CID) in Arabian foals appears to be similar to CID in children. The disease is characterized by a deficiency of T and B lymphocytes. Immunotherapy was attempted in 2 Arabian foals with combined immunodeficiency. One foal was given a transplant of bone marrow from a selected full sibling, and 1 foal was given a fetal thymus transplant. Both foals died. Genetic evidence was obtained for survival of the transplanted tissues in both cases; however, a graft versus host reaction developed in the foal given the fetal thymus transplant.

Original languageEnglish (US)
Pages (from-to)167-175
Number of pages9
JournalJournal of the American Veterinary Medical Association
Volume170
Issue number2
StatePublished - Oct 3 1977

ASJC Scopus subject areas

  • veterinary(all)

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    Ardans, A., Trommershausen-Smith, A., Osburn, B., Mayhew, I. G., Trees, C., Park, M. I., Sawyer, M., & Stabenfeldt, G. H. (1977). Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction. Journal of the American Veterinary Medical Association, 170(2), 167-175.