Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction

Alex Ardans, A. Trommershausen-Smith, Bennie Osburn, I. G. Mayhew, C. Trees, M. I. Park, M. Sawyer, G. H. Stabenfeldt

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Combined immunodeficiency (CID) in Arabian foals appears to be similar to CID in children. The disease is characterized by a deficiency of T and B lymphocytes. Immunotherapy was attempted in 2 Arabian foals with combined immunodeficiency. One foal was given a transplant of bone marrow from a selected full sibling, and 1 foal was given a fetal thymus transplant. Both foals died. Genetic evidence was obtained for survival of the transplanted tissues in both cases; however, a graft versus host reaction developed in the foal given the fetal thymus transplant.

Original languageEnglish (US)
Pages (from-to)167-175
Number of pages9
JournalJournal of the American Veterinary Medical Association
Volume170
Issue number2
StatePublished - Oct 3 1977

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graft versus host reactions
immunotherapy
immunosuppression
foals
Immunotherapy
Transplants
Arabian (horse breed)
Thymus Gland
Tissue Survival
Siblings
bone marrow transplant
B-Lymphocytes
Bone Marrow
T-Lymphocytes
B-lymphocytes
T-lymphocytes

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Ardans, A., Trommershausen-Smith, A., Osburn, B., Mayhew, I. G., Trees, C., Park, M. I., ... Stabenfeldt, G. H. (1977). Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction. Journal of the American Veterinary Medical Association, 170(2), 167-175.

Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction. / Ardans, Alex; Trommershausen-Smith, A.; Osburn, Bennie; Mayhew, I. G.; Trees, C.; Park, M. I.; Sawyer, M.; Stabenfeldt, G. H.

In: Journal of the American Veterinary Medical Association, Vol. 170, No. 2, 03.10.1977, p. 167-175.

Research output: Contribution to journalArticle

Ardans, A, Trommershausen-Smith, A, Osburn, B, Mayhew, IG, Trees, C, Park, MI, Sawyer, M & Stabenfeldt, GH 1977, 'Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction', Journal of the American Veterinary Medical Association, vol. 170, no. 2, pp. 167-175.
Ardans, Alex ; Trommershausen-Smith, A. ; Osburn, Bennie ; Mayhew, I. G. ; Trees, C. ; Park, M. I. ; Sawyer, M. ; Stabenfeldt, G. H. / Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction. In: Journal of the American Veterinary Medical Association. 1977 ; Vol. 170, No. 2. pp. 167-175.
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