Immunotherapy following hematopoietic stem cell transplantation: Potential for synergistic effects

Myriam N. Bouchlaka, Doug Redelman, William J Murphy

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Hematopoietic stem cell transplantation (HSCT) is a particularly important treatment for hematologic malignancies. Unfortunately, following allogeneic HSCT, graft-versus-host disease, immunosuppression and susceptibility to opportunistic infections remain among the most substantial problems restricting the efficacy and use of this procedure, particularly for cancer. Adoptive immunotherapy and/or manipulation of the graft offer ways to attack residual cancer as well as other transplant-related complications. Recent exciting discoveries have demonstrated that HSCT could be expanded to solid tissue cancers with profound effects on the effectiveness of adoptive immunotherapy. This review will provide a background regarding HSCT, discuss the complications that make it such a complex treatment procedure following up with current immunotherapeutic strategies and discuss emerging approaches in applying immunotherapy in HSCT for cancer.

Original languageEnglish (US)
Pages (from-to)399-418
Number of pages20
JournalImmunotherapy
Volume2
Issue number3
DOIs
StatePublished - May 2010

Keywords

  • Adoptive immunotherapy
  • Antigen-presenting cell
  • Graft-versus-host disease
  • Graft-versus-leukemia
  • Graft-versus-tumor
  • Hematopoietic stem cell transplantation
  • Myeloablative conditioning
  • Natural killer cell
  • Nonmyeloablative conditioning
  • Regulatory T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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