Abstract
Hematopoietic stem cell transplantation (HSCT) is a particularly important treatment for hematologic malignancies. Unfortunately, following allogeneic HSCT, graft-versus-host disease, immunosuppression and susceptibility to opportunistic infections remain among the most substantial problems restricting the efficacy and use of this procedure, particularly for cancer. Adoptive immunotherapy and/or manipulation of the graft offer ways to attack residual cancer as well as other transplant-related complications. Recent exciting discoveries have demonstrated that HSCT could be expanded to solid tissue cancers with profound effects on the effectiveness of adoptive immunotherapy. This review will provide a background regarding HSCT, discuss the complications that make it such a complex treatment procedure following up with current immunotherapeutic strategies and discuss emerging approaches in applying immunotherapy in HSCT for cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 399-418 |
| Number of pages | 20 |
| Journal | Immunotherapy |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2010 |
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Keywords
- Adoptive immunotherapy
- Antigen-presenting cell
- Graft-versus-host disease
- Graft-versus-leukemia
- Graft-versus-tumor
- Hematopoietic stem cell transplantation
- Myeloablative conditioning
- Natural killer cell
- Nonmyeloablative conditioning
- Regulatory T cell
ASJC Scopus subject areas
- Immunology and Allergy
- Oncology
- Immunology