Immunotherapeutic suppression in transplantable solid tumours

Gerald J. Mizejewski, Roblee P Allen

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

α-FOETOPROTEIN (AFP) is a glycoprotein, of unknown function, synthesised by the foetal liver and yolk sac of mammals1. Increased serum levels of AFP in adults are indicative of either pregnancy or a pathological state, that is primary hepatocellular carcinoma, regenerating liver and teratoblastomas of the ovary and testis2,3. Recently, abnormal levels of AFP in amniotic fluids have been correlated with foetal distress 4. While attempting to study the physiological role of AFP during ontogenic and oncogenic growth, we have observed an interaction between AFP and its homologous antiserum that may have immunotherapeutic value. We report here the suppression of mouse hepatoma growth in vivo and in vitro using passively administered antiserum to AFP.

Original languageEnglish (US)
Pages (from-to)50-52
Number of pages3
JournalNature
Volume250
Issue number5461
DOIs
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • General

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