Immunosuppressive activity of rhesus monkey pregnancy serum

Larry R. Ellingsworth, Linda G. Hayashi, Bennie Osburn, Charles A. Holmberg

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Normal pregnancy serum from the rhesus monkey was found to have immunosuppressive activity. Using two-way stimulation, the mixed lymphocyte response was suppressed as much as 80%. Control serum from nonpregnant females was not suppressive. The inhibiting factor was found to have the following characteristics: (1) it was nonspecific in activity; (2) it inhibited the mixed lymphocyte response 20% at in vitro concentrations of 1%; (3) it was heat stable (56° C for 30 minutes) and nondialyzable; (4) it was present in both the IgM- and IgG-containing fractions of pregnancy serum; (5) it was detected in postpartum and second and third trimester serum; and (6) it was at low levels or absent from the serum of two pregnancies which terminated in unexplained stillbirths.

Original languageEnglish (US)
Pages (from-to)932-936
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume139
Issue number8
DOIs
StatePublished - Apr 15 1981

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Immunosuppressive Agents
Macaca mulatta
Pregnancy
Serum
Stillbirth
Third Pregnancy Trimester
Second Pregnancy Trimester
Lymphocyte Activation
Postpartum Period
Immunoglobulin M
Immunoglobulin G
Hot Temperature
Lymphocytes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Immunosuppressive activity of rhesus monkey pregnancy serum. / Ellingsworth, Larry R.; Hayashi, Linda G.; Osburn, Bennie; Holmberg, Charles A.

In: American Journal of Obstetrics and Gynecology, Vol. 139, No. 8, 15.04.1981, p. 932-936.

Research output: Contribution to journalArticle

Ellingsworth, Larry R. ; Hayashi, Linda G. ; Osburn, Bennie ; Holmberg, Charles A. / Immunosuppressive activity of rhesus monkey pregnancy serum. In: American Journal of Obstetrics and Gynecology. 1981 ; Vol. 139, No. 8. pp. 932-936.
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