Immunosuppressive activity of rhesus monkey pregnancy serum

Larry R. Ellingsworth, Linda G. Hayashi, Bennie Osburn, Charles A. Holmberg

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1 Scopus citations


Normal pregnancy serum from the rhesus monkey was found to have immunosuppressive activity. Using two-way stimulation, the mixed lymphocyte response was suppressed as much as 80%. Control serum from nonpregnant females was not suppressive. The inhibiting factor was found to have the following characteristics: (1) it was nonspecific in activity; (2) it inhibited the mixed lymphocyte response 20% at in vitro concentrations of 1%; (3) it was heat stable (56° C for 30 minutes) and nondialyzable; (4) it was present in both the IgM- and IgG-containing fractions of pregnancy serum; (5) it was detected in postpartum and second and third trimester serum; and (6) it was at low levels or absent from the serum of two pregnancies which terminated in unexplained stillbirths.

Original languageEnglish (US)
Pages (from-to)932-936
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number8
StatePublished - Apr 15 1981

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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