Immunoreactivity of Canine Liposarcoma to Muscle and Brown Adipose Antigens

Elise E.B. LaDouceur, Sarah E. Stevens, Jason Wood, Christopher M. Reilly

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Liposarcoma, rhabdomyosarcoma, and hibernoma share some overlapping histologic and immunohistochemical features. Although immunohistochemistry (IHC) is commonly used in the diagnosis of these neoplasms, expression of muscle markers has been reported in human liposarcoma and canine hibernoma in addition to rhabdomyosarcoma. Thus, these neoplasms are a diagnostic challenge but important to distinguish because of differences in prognosis and treatment. Rhabdomyosarcoma and liposarcoma are both malignant, but rhabdomyosarcoma has a higher potential for metastasis. In contrast, hibernomas are benign with low risk of recurrence. This study investigated expression of the muscle markers desmin, myogenin, and α-smooth muscle actin (α-SMA) and the brown fat marker uncoupling protein 1 (UCP1) in 25 cases of canine liposarcoma using IHC. Oil red O histochemistry was performed to confirm the presence of lipid and the diagnosis of liposarcoma in cases that were not well-differentiated. The 25 cases included 15 well-differentiated, 5 pleomorphic, 3 myxoid, and 2 dedifferentiated subtypes of liposarcoma. By IHC, 23 of 25 expressed UCP1, 7 of 25 expressed α-SMA, 7 of 25 expressed desmin, and 3 of 25 expressed myogenin with no clear relationship of antigen expression and tumor subtype. These findings clarify the immunohistochemical profile of canine liposarcoma and suggest overlap in the expression of several muscle antigens and UCP1 between liposarcoma, hibernoma, and rhabdomyosarcoma.

Original languageEnglish (US)
Pages (from-to)885-891
Number of pages7
JournalVeterinary Pathology
Volume54
Issue number6
DOIs
StatePublished - Nov 1 2017

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Keywords

  • desmin
  • dog
  • immunohistochemistry
  • liposarcoma
  • myogenin
  • neoplasia
  • uncoupling protein 1
  • α-smooth muscle actin

ASJC Scopus subject areas

  • veterinary(all)

Cite this

LaDouceur, E. E. B., Stevens, S. E., Wood, J., & Reilly, C. M. (2017). Immunoreactivity of Canine Liposarcoma to Muscle and Brown Adipose Antigens. Veterinary Pathology, 54(6), 885-891. https://doi.org/10.1177/0300985817723691