Immunoprophylactic strategies against enterotoxemia caused by Clostridium perfringens type D in goats

Josir Laine A Veschi, Iveraldo S. Dutra, Mariano E. Fernandez Miyakawa, Silvia Helena V Perri, Francisco A Uzal

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The serological response to an experimental vaccine against Clostridium perfringens type D enterotoxemia was evaluated in four groups of goats. Group 1 received colostrum from unvaccinated cows and no vaccine. Groups 2, 3 and 4 received colostrum from vaccinated cows. In addition, Groups 3 and 4 received a vaccine close at 80 days of age, and Group 4 received a second vaccine dose at 120 days of age. Serum antibody levels were determined by ELISA in cows before and after calving, and in goats at 3, 80, 120 and 160 days of age. No significant difference in serum antibody levels was observed between vaccinated and unvaccinated cows, or between the four groups of goats evaluated at 3 days of life. Groups 3 and 4 presented mean antibody titers of 0.6 and 1.1 IU/ml, respectively, 40 days after first vaccination. The vaccine response of Group 4 was 1.8 IU/ml 40 days after the booster dose and was higher than that observed for Group 3 (0.2 IU/ml). Thus, in the proposed regimen the use of heterologous colostrum did not induce passive immunization in goat kids. However, first vaccination and a booster dose after 40 days triggered satisfactory antibody levels.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalPesquisa Veterinaria Brasileira
Issue number1
StatePublished - Jan 2006


  • Clostridium perfringens type d
  • Colostrum
  • Enterotoxemia
  • Goat
  • Immunoprophylactic strategies
  • Vaccine

ASJC Scopus subject areas

  • veterinary(all)


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