Immunophenotyping Lymphomas in Dogs: A Comparison of Results From Fine Needle Aspirate and Needle Biopsy Samples

D. J. Fisher, D. Naydan, L. L. Werner, Peter F Moore

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The reliability of utilizing cytologic samples for immunophenotyping canine lymphomas was evaluated by a systematic comparison of results from fine needle aspirate (FNA) to needle biopsy specimens stained by immunochemical methods. The specific reactivity of a selected panel of 12 antibodies to cell surface markers and intermediate filaments was assessed in 11 dogs by comparing cytologic to histologic samples. There was excellent correlation of results between immunostained cytologic and histologic samples. FNA sampling is a simple, noninvasive method for determining the lymphoid phenotype in canine lymphoma. In addition, this technique may be useful as a cytodiagnostic aid in differentiating lymphoid from non‐lymphoid tumors and in assessing neoplastic vs. reactive or hyperplastic processes.

Original languageEnglish (US)
Pages (from-to)118-123
Number of pages6
JournalVeterinary Clinical Pathology
Volume24
Issue number4
DOIs
StatePublished - 1995

Keywords

  • dog
  • Immunocytochemistry
  • immunophenotype
  • intermediate filaments
  • lymphoma
  • surface markers

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint Dive into the research topics of 'Immunophenotyping Lymphomas in Dogs: A Comparison of Results From Fine Needle Aspirate and Needle Biopsy Samples'. Together they form a unique fingerprint.

  • Cite this