Immunophenotyping Lymphomas in Dogs: A Comparison of Results From Fine Needle Aspirate and Needle Biopsy Samples

D. J. Fisher, D. Naydan, L. L. Werner, Peter F Moore

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The reliability of utilizing cytologic samples for immunophenotyping canine lymphomas was evaluated by a systematic comparison of results from fine needle aspirate (FNA) to needle biopsy specimens stained by immunochemical methods. The specific reactivity of a selected panel of 12 antibodies to cell surface markers and intermediate filaments was assessed in 11 dogs by comparing cytologic to histologic samples. There was excellent correlation of results between immunostained cytologic and histologic samples. FNA sampling is a simple, noninvasive method for determining the lymphoid phenotype in canine lymphoma. In addition, this technique may be useful as a cytodiagnostic aid in differentiating lymphoid from non‐lymphoid tumors and in assessing neoplastic vs. reactive or hyperplastic processes.

Original languageEnglish (US)
Pages (from-to)118-123
Number of pages6
JournalVeterinary Clinical Pathology
Volume24
Issue number4
DOIs
StatePublished - 1995

Fingerprint

Immunophenotyping
Needle Biopsy
lymphoma
Needles
Canidae
biopsy
Lymphoma
Dogs
Intermediate Filaments
dogs
Phenotype
sampling
intermediate filaments
Antibodies
Neoplasms
methodology
phenotype
neoplasms
antibodies
cells

Keywords

  • dog
  • Immunocytochemistry
  • immunophenotype
  • intermediate filaments
  • lymphoma
  • surface markers

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Immunophenotyping Lymphomas in Dogs : A Comparison of Results From Fine Needle Aspirate and Needle Biopsy Samples. / Fisher, D. J.; Naydan, D.; Werner, L. L.; Moore, Peter F.

In: Veterinary Clinical Pathology, Vol. 24, No. 4, 1995, p. 118-123.

Research output: Contribution to journalArticle

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