Immunopathogenesis of primary biliary cirrhosis: An old wives' tale

Daniel S. Smyk, Eirini I. Rigopoulou, Ana Lleo, Robin D. Abeles, Athanasios Mavropoulos, Charalambos Billinis, Pietro Invernizzi, Dimitrios P. Bogdanos

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the autoimmune destruction of the small intrahepatic bile ducts. The disease has an unpredictable clinical course, but may progress to fibrosis and cirrhosis. Although medical treatment with urseodeoxycholic acid is largely successful, some patients may progress to liver failure requiring liver transplantation. PBC is characterised by the presence of disease specific anti-mitochondrial (AMA) antibodies, which are pathognomonic for PBC development. The disease demonstrates an overwhelming female preponderance and virtually all women with PBC present in middle age. The reasons for this are unknown; however several environmental and immunological factors may be involved. As the immune systems ages, it become less self tolerant, and mounts a weaker response to pathogens, possibly leading to cross reactivity or molecular mimicry. Some individuals display immunological changes which encourage the development of autoimmune disease. Risk factors implicated in PBC include recurrent urinary tract infection in females, as well as an increased prevalence of reproductive complications. These risk factors may work in concert with and possibly even accelerate, immune system ageing, contributing to PBC development. This review will examine the changes that occur in the immune system with ageing, paying particular attention to those changes which contribute to the development of autoimmune disease with increasing age. The review also discusses risk factors which may account for the increased female predominance of PBC, such as recurrent UTI and oestrogens.

Original languageEnglish (US)
Article number12
JournalImmunity and Ageing
Volume8
DOIs
StatePublished - Dec 2 2011

Keywords

  • Ageing
  • Apoptosis
  • Autoantibody
  • Autoimmunity
  • Infection

ASJC Scopus subject areas

  • Immunology
  • Aging

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  • Cite this

    Smyk, D. S., Rigopoulou, E. I., Lleo, A., Abeles, R. D., Mavropoulos, A., Billinis, C., Invernizzi, P., & Bogdanos, D. P. (2011). Immunopathogenesis of primary biliary cirrhosis: An old wives' tale. Immunity and Ageing, 8, [12]. https://doi.org/10.1186/1742-4933-8-12