Abstract
Peptide T is an octapeptide from the V2 region of HIV-1 gp120. It has been shown to resolve psoriatic lesions - an inflammatory skin disease. The mechanisms of anti-inflammatory actions of peptide T are not well understood. Th1 cytokines such as IL-2, and IFN-γ are upregulated in psoriasis. These cytokines play a key role in the inflammatory and proliferative processes of psoriasis. The effects of peptide T on Th1 and Th2 cytokines were studied in order to elucidate the mechanisms of antiinflammatory actions of peptide T. It was observed that peptide T at 10-8 M induces IL-10 production by the human Th2 cell line and PBMC (P<0.05, ANOVA). Also peptide T at 10-9 M concentration significantly inhibited IFN-γ production by PBMC (P<0.001, ANOVA). Anti IL-10 antibody inhibited the anti-IFN-γ effect of peptide T (P<0.05, t-test). Our study shows that peptide T induces IL-10 production and inhibits IFN-γ production. IL-10 is a potent anti-inflammatory cytokine. It inhibits IL-2 and IFN- γ production from the T cells and downregulates the expression of TNF-α in the antigen presenting cells. Recently, IL-10 has been shown to resolve psoriatic lesions. The effects of peptide T on IL-10 and IFN-γ production provides a plausible explanation for its clinical efficacy in psoriasis. Copyright (C) 1999.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 609-615 |
| Number of pages | 7 |
| Journal | International Journal of Immunopharmacology |
| Volume | 21 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Pharmacology
Cite this
Immunomodulatory effects of peptide T on Th 1/Th 2 cytokines. / Raychaudhuri, Siba P; Farber, Eugene M.; Raychaudhuri, Smriti K.
In: International Journal of Immunopharmacology, Vol. 21, No. 9, 09.1999, p. 609-615.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunomodulatory effects of peptide T on Th 1/Th 2 cytokines
AU - Raychaudhuri, Siba P
AU - Farber, Eugene M.
AU - Raychaudhuri, Smriti K.
PY - 1999/9
Y1 - 1999/9
N2 - Peptide T is an octapeptide from the V2 region of HIV-1 gp120. It has been shown to resolve psoriatic lesions - an inflammatory skin disease. The mechanisms of anti-inflammatory actions of peptide T are not well understood. Th1 cytokines such as IL-2, and IFN-γ are upregulated in psoriasis. These cytokines play a key role in the inflammatory and proliferative processes of psoriasis. The effects of peptide T on Th1 and Th2 cytokines were studied in order to elucidate the mechanisms of antiinflammatory actions of peptide T. It was observed that peptide T at 10-8 M induces IL-10 production by the human Th2 cell line and PBMC (P<0.05, ANOVA). Also peptide T at 10-9 M concentration significantly inhibited IFN-γ production by PBMC (P<0.001, ANOVA). Anti IL-10 antibody inhibited the anti-IFN-γ effect of peptide T (P<0.05, t-test). Our study shows that peptide T induces IL-10 production and inhibits IFN-γ production. IL-10 is a potent anti-inflammatory cytokine. It inhibits IL-2 and IFN- γ production from the T cells and downregulates the expression of TNF-α in the antigen presenting cells. Recently, IL-10 has been shown to resolve psoriatic lesions. The effects of peptide T on IL-10 and IFN-γ production provides a plausible explanation for its clinical efficacy in psoriasis. Copyright (C) 1999.
AB - Peptide T is an octapeptide from the V2 region of HIV-1 gp120. It has been shown to resolve psoriatic lesions - an inflammatory skin disease. The mechanisms of anti-inflammatory actions of peptide T are not well understood. Th1 cytokines such as IL-2, and IFN-γ are upregulated in psoriasis. These cytokines play a key role in the inflammatory and proliferative processes of psoriasis. The effects of peptide T on Th1 and Th2 cytokines were studied in order to elucidate the mechanisms of antiinflammatory actions of peptide T. It was observed that peptide T at 10-8 M induces IL-10 production by the human Th2 cell line and PBMC (P<0.05, ANOVA). Also peptide T at 10-9 M concentration significantly inhibited IFN-γ production by PBMC (P<0.001, ANOVA). Anti IL-10 antibody inhibited the anti-IFN-γ effect of peptide T (P<0.05, t-test). Our study shows that peptide T induces IL-10 production and inhibits IFN-γ production. IL-10 is a potent anti-inflammatory cytokine. It inhibits IL-2 and IFN- γ production from the T cells and downregulates the expression of TNF-α in the antigen presenting cells. Recently, IL-10 has been shown to resolve psoriatic lesions. The effects of peptide T on IL-10 and IFN-γ production provides a plausible explanation for its clinical efficacy in psoriasis. Copyright (C) 1999.
UR - http://www.scopus.com/inward/record.url?scp=0032856047&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032856047&partnerID=8YFLogxK
U2 - 10.1016/S0192-0561(99)00041-7
DO - 10.1016/S0192-0561(99)00041-7
M3 - Article
C2 - 10501630
AN - SCOPUS:0032856047
VL - 21
SP - 609
EP - 615
JO - International Immunopharmacology
JF - International Immunopharmacology
SN - 1567-5769
IS - 9
ER -