Immunomodulatory effects of peptide T on Th 1/Th 2 cytokines

Siba P Raychaudhuri, Eugene M. Farber, Smriti K. Raychaudhuri

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Peptide T is an octapeptide from the V2 region of HIV-1 gp120. It has been shown to resolve psoriatic lesions - an inflammatory skin disease. The mechanisms of anti-inflammatory actions of peptide T are not well understood. Th1 cytokines such as IL-2, and IFN-γ are upregulated in psoriasis. These cytokines play a key role in the inflammatory and proliferative processes of psoriasis. The effects of peptide T on Th1 and Th2 cytokines were studied in order to elucidate the mechanisms of antiinflammatory actions of peptide T. It was observed that peptide T at 10-8 M induces IL-10 production by the human Th2 cell line and PBMC (P<0.05, ANOVA). Also peptide T at 10-9 M concentration significantly inhibited IFN-γ production by PBMC (P<0.001, ANOVA). Anti IL-10 antibody inhibited the anti-IFN-γ effect of peptide T (P<0.05, t-test). Our study shows that peptide T induces IL-10 production and inhibits IFN-γ production. IL-10 is a potent anti-inflammatory cytokine. It inhibits IL-2 and IFN- γ production from the T cells and downregulates the expression of TNF-α in the antigen presenting cells. Recently, IL-10 has been shown to resolve psoriatic lesions. The effects of peptide T on IL-10 and IFN-γ production provides a plausible explanation for its clinical efficacy in psoriasis. Copyright (C) 1999.

Original languageEnglish (US)
Pages (from-to)609-615
Number of pages7
JournalInternational Journal of Immunopharmacology
Volume21
Issue number9
DOIs
StatePublished - Sep 1999
Externally publishedYes

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Peptide T
Cytokines
Interleukin-10
Psoriasis
Anti-Inflammatory Agents
Interleukin-2
Analysis of Variance
Th2 Cells
Antigen-Presenting Cells
Skin Diseases
HIV-1
Anti-Idiotypic Antibodies
Down-Regulation
T-Lymphocytes
Cell Line

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Immunomodulatory effects of peptide T on Th 1/Th 2 cytokines. / Raychaudhuri, Siba P; Farber, Eugene M.; Raychaudhuri, Smriti K.

In: International Journal of Immunopharmacology, Vol. 21, No. 9, 09.1999, p. 609-615.

Research output: Contribution to journalArticle

Raychaudhuri, Siba P ; Farber, Eugene M. ; Raychaudhuri, Smriti K. / Immunomodulatory effects of peptide T on Th 1/Th 2 cytokines. In: International Journal of Immunopharmacology. 1999 ; Vol. 21, No. 9. pp. 609-615.
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