Immunology of autism

Destanie R. Rose, Paul Ashwood

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Autism spectrum disorders (ASD) are developmental disorders characterized by behavioral deficits in verbal and nonverbal communication as well as social interactions, and are accompanied by repetitive or stereotyped behaviors and interests. Numerous studies over the last forty years have recognized altered immune responses in individuals with ASD; concurrently basic research has highlighted the myriad of neuroimmune interactions and the cross talk that occurs between nervous and immune systems. Neuroinflammation, particularly in the cerebellum, has been found in post mortem brain tissues from individuals with ASD and is characterized by the presence of profound glia activation processes. This and altered gene expression profiles indicating perturbed immune suggest a contributing role for immunological systems in the pathology of ASD. Peripheral immune abnormalities have also been found; shifts in both direction of Th1 and Th2 skewing have been reported as well as autoantibody production, increased NK cell activation, T cell responses and monocyte cell function overwhelmingly suggesting the presence of immune dysfunction in individuals with ASD. Many of these findings are associated with worsening behavioral scores, suggesting treatment of immune function could be useful in alleviating symptoms associated with ASD. Immune activation in utero is also associated with an increased risk of the child for having a diagnosis of ASD, where increased cytokine production in the offspring is directly linked to changes in offspring behavior. In addition to peripheral changes, brain and CSF immune variations in ASD are reported as well as an increase in gastrointestinal/mucosal dysfunction which has led to an increased interest in exploring the gut-brain-immune connections and its role in ASD. Further research in neuroimmune interactions may bring further insight and elicit new therapeutic tools for ASD.

Original languageEnglish (US)
Title of host publicationThe Molecular Basis of Autism
PublisherSpringer New York
Pages93-115
Number of pages23
ISBN (Print)9781493921904, 9781493921898
DOIs
StatePublished - Jan 1 2015

Fingerprint

Autistic Disorder
Allergy and Immunology
Brain
Autism Spectrum Disorder
Nonverbal Communication
Stereotyped Behavior
Interpersonal Relations
Transcriptome
Research
Neuroglia
Natural Killer Cells
Autoantibodies
Cerebellum
Nervous System
Monocytes
Immune System
Pathology
Cytokines
T-Lymphocytes
Therapeutics

Keywords

  • Adaptive immune system
  • Autism spectrum disorders
  • Behavior
  • Cerebellum
  • Cytokine
  • Gastrointestinal
  • Immunity
  • Innate immune system
  • Maternal immune activation
  • Neuroimmunology
  • Social interactions
  • T cells

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)
  • Psychology(all)

Cite this

Rose, D. R., & Ashwood, P. (2015). Immunology of autism. In The Molecular Basis of Autism (pp. 93-115). Springer New York. https://doi.org/10.1007/978-1-4939-2190-4_6

Immunology of autism. / Rose, Destanie R.; Ashwood, Paul.

The Molecular Basis of Autism. Springer New York, 2015. p. 93-115.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rose, DR & Ashwood, P 2015, Immunology of autism. in The Molecular Basis of Autism. Springer New York, pp. 93-115. https://doi.org/10.1007/978-1-4939-2190-4_6
Rose DR, Ashwood P. Immunology of autism. In The Molecular Basis of Autism. Springer New York. 2015. p. 93-115 https://doi.org/10.1007/978-1-4939-2190-4_6
Rose, Destanie R. ; Ashwood, Paul. / Immunology of autism. The Molecular Basis of Autism. Springer New York, 2015. pp. 93-115
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