Immunology of atopic dermatitis: novel insights into mechanisms and immunomodulatory therapies.

Caitlin T. Harskamp, April W. Armstrong

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin condition that is associated with immune dysregulation and epidermal barrier dysfunction. The imbalance of the Th2 and Th1 pathways and their associated cytokines in AD presents as one facet of the pathogenic mechanisms. Changes in the T-cell populations and the associated cytokines during the acute and chronic phases of AD can cause variations in disease presentations and treatment responses. Continued discoveries in the immunopathogenesis of AD provide optimism for the development of efficacious therapeutic agents. Novel immunomodulatory therapies include apremilast, dupilumab, IL-37, omalizumab, rituximab, mepolizumab, infliximab, allergen-specific immunotherapy, Mycobacterium vaccae, and leflunomide. These agents serve as examples of how modulation in immunopathogenesis of AD can lead to therapeutic discoveries.

Original languageEnglish (US)
Pages (from-to)132-139
Number of pages8
JournalSeminars in Cutaneous Medicine and Surgery
Volume32
Issue number3
StatePublished - Sep 2013
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology
  • Surgery
  • Medicine(all)

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