Immunological tolerance to allergenic protein determinants: A therapeutic approach for selective inhibition of IgE antibody production

Fu-Tong Liu, D. H. Katz

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Administration of stable conjugates prepared by coupling protein antigens such as ovalbumin or antigen E of ragweed extract to the synthetic random copolymer of D-glutamic acid and D-lysine (D-GL) is effective in inducing a state of long-lasting, antigen-sepcific immunological tolerance in experimental animals. A striking aspect of the tolerance induced by protein-D-GL conjugates is the remarkable selectivity of the tolerance for antibody responses of the IgE class. Protein-D-GL conjugates of either type were capable of inducing such tolerance both in unsensitized and in previously sensitized animals when administered in appropriate doses. Comparable doses of conjugated proteins were likewise capable of suppressing IgE antibody production, although the duration of suppression in these cases was significantly less than that observed with protein-D-GL conjugates. If such conjugates act in man as they do in experimental animals, they could be of great value as therapeutic agents in selectively diminishing IgE antibody production while sparing antibody production in the IgG class.

Original languageEnglish (US)
Pages (from-to)1430-1434
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number3
StatePublished - 1979

ASJC Scopus subject areas

  • General
  • Genetics

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