TY - JOUR
T1 - Immunological similarities between primary sclerosing cholangitis and chronic sclerosing sialadenitis
T2 - Report of the overlapping of these two autoimmune diseases
AU - Tsuneyama, Koichi
AU - Saito, Katsuhiko
AU - Ruebner, Boris H.
AU - Konishi, Ichiro
AU - Nakanuma, Yasuni
AU - Gershwin, M. Eric
PY - 2000
Y1 - 2000
N2 - Primary sclerosing cholangitis (PSC) is characterized by destructive inflammation and fibrosis affecting the bile ducts. The etiology of PSC is still unknown, although lymphocytic infiltration in the portal areas suggests an immune-mediated destruction of the bile ducts. Patients with one autoimmune disease often suffer from one or more other autoimmune diseases. It is well known that there is a close relationship between PSC and inflammatory bowel disease, particularly ulcerative colitis(UC). However, the pathological findings in UC and other overlap diseases do not resemble those of PSC. In the present study, we report a patient with chronic sclerosing sialadenitis (Kuttner's tumor) and PSC. It is compared the sclerosing changes in both salivary glands and bile ducts histologically. In addition, the expression pattern of mast cell tryptase, b-FGF, and HLA-DR were examined in both tissues immunohistochemically. Histological features of sclerosing change in both salivary and bile ducts were quite similar. Marked mast cell infiltration and b-FGF expression were seen in the sclerosing areas in both tissues. In active inflammatory areas of the salivary glands, HLA-DR expression was also seen. We hypothesized that similar immune reactions occur in both the salivary gland and bile ducts and are responsible for the fibrosis that follows.
AB - Primary sclerosing cholangitis (PSC) is characterized by destructive inflammation and fibrosis affecting the bile ducts. The etiology of PSC is still unknown, although lymphocytic infiltration in the portal areas suggests an immune-mediated destruction of the bile ducts. Patients with one autoimmune disease often suffer from one or more other autoimmune diseases. It is well known that there is a close relationship between PSC and inflammatory bowel disease, particularly ulcerative colitis(UC). However, the pathological findings in UC and other overlap diseases do not resemble those of PSC. In the present study, we report a patient with chronic sclerosing sialadenitis (Kuttner's tumor) and PSC. It is compared the sclerosing changes in both salivary glands and bile ducts histologically. In addition, the expression pattern of mast cell tryptase, b-FGF, and HLA-DR were examined in both tissues immunohistochemically. Histological features of sclerosing change in both salivary and bile ducts were quite similar. Marked mast cell infiltration and b-FGF expression were seen in the sclerosing areas in both tissues. In active inflammatory areas of the salivary glands, HLA-DR expression was also seen. We hypothesized that similar immune reactions occur in both the salivary gland and bile ducts and are responsible for the fibrosis that follows.
KW - B-FGF
KW - Chronic sclerosing sialadenitis
KW - HLA-DR
KW - Mast cell
KW - Primary sclerosing cholangitis
UR - http://www.scopus.com/inward/record.url?scp=0034050387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034050387&partnerID=8YFLogxK
U2 - 10.1023/A:1005429130150
DO - 10.1023/A:1005429130150
M3 - Article
C2 - 10711453
AN - SCOPUS:0034050387
VL - 45
SP - 366
EP - 372
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 2
ER -