Immunological characterization of a low oncogenic mouse mammary tumor virus from BALB/cNIV mice

J. P. Vacquier, Robert Cardiff, P. B. Blair

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Abstract

Antigenic determinants of mouse mammary tumor virus (MuMTV) from the low-mammary-tumor-incidence strain BALB/cNIV were compared by competition radioimmunoassay with those of MuMTV's isolated from several high- and low-mammary-tumor-incidence mouse strains, using rabbit hyperimmune sera against BALB/cNIV MuMTV and against MuMTV from the high-mammary-tumor-incidence strain BALB/cfC3H. Using anti-BALB/cfC3H serum in competition radioimmunoassay, BALB/cNIV MuMTV lacked antigenic determinants present on MuMTV's from the BALB/cfC3H, C3H, and GR strains. With anti-BALB/cNIV serum in competition radioimmunoassay, type-specific antigenicity was detected with BALB/cNIV MuMTV. We found class-specific antigenicities on BALB/cNIV MuMTV that were shared with RIII and C3Hf MuMTV's. BALB/cNIV MuMTV was reportedly derived from the C3Hf strain by infection of BALB/c mouse mammary tissue after transplantation into a (BALB/c x C3Hf)F1 hybrid followed by retransplantation into the BALB/c strain (D.R. Pitelka, K.B. DeOme, and H.A. Bern. Proc. Am. Assoc. Cancer Res. 6:51, 1965). However, BALB/cNIV MuMTV contained type-specific antigens not present on C3Hf MuMTV. The possible origin of these determinants is discussed.

Original languageEnglish (US)
Pages (from-to)56-64
Number of pages9
JournalJournal of Virology
Volume40
Issue number1
StatePublished - Dec 1 1981

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ASJC Scopus subject areas

  • Immunology

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