Immunologic responses and adverse reactions to Freund's-adjuvanted porcine zona pellucida immunocontraceptives in domestic cats

L. Munson, L. A. Harrenstien, A. E. Acton, P. A. Graham, L. M. Chassy, J. F. Kirkpatrick

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A vaccine of native PZP with Freund's adjuvant has been widely used in zoo and wild ungulates, but safety in felids has not been evaluated. General health, immune response, and ovarian histology were assessed in five domestic cats vaccinated with PZP-Freund's and five cats given Freund's adjuvant alone. Peak antibody titers occurred 3 weeks after the third vaccination, and no ovarian lesions were present 6 months after vaccination. Seven cats developed extensive granulomatous reactions at injection sites, lymph nodes, and multiple visceral organs including lungs and brain. Persistent hypercalcemia and compromised renal function occurred in three cats with elevated serum calcitriol of probable macrophage origin. One cat died from an injection site sarcoma. Because of these severe adverse reactions, Freund's adjuvant is contraindicated in cats, and other adjuvants for PZP vaccines should be tested in cats for adverse reactions before use.

Original languageEnglish (US)
Pages (from-to)5646-5654
Number of pages9
JournalVaccine
Volume23
Issue number48-49
DOIs
StatePublished - Dec 1 2005

Fingerprint

Zona Pellucida
zona pellucida
Cats
Swine
cats
swine
Freund's Adjuvant
adjuvants
injection site
Vaccination
Vaccines
vaccination
hypercalcemia
calcitriol
vaccine adjuvants
Injections
Felidae
Calcitriol
sarcoma
Hypercalcemia

Keywords

  • Freund's adjuvant
  • Hypercalcemia
  • Porcine zona pellucida

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Munson, L., Harrenstien, L. A., Acton, A. E., Graham, P. A., Chassy, L. M., & Kirkpatrick, J. F. (2005). Immunologic responses and adverse reactions to Freund's-adjuvanted porcine zona pellucida immunocontraceptives in domestic cats. Vaccine, 23(48-49), 5646-5654. https://doi.org/10.1016/j.vaccine.2005.05.044

Immunologic responses and adverse reactions to Freund's-adjuvanted porcine zona pellucida immunocontraceptives in domestic cats. / Munson, L.; Harrenstien, L. A.; Acton, A. E.; Graham, P. A.; Chassy, L. M.; Kirkpatrick, J. F.

In: Vaccine, Vol. 23, No. 48-49, 01.12.2005, p. 5646-5654.

Research output: Contribution to journalArticle

Munson, L, Harrenstien, LA, Acton, AE, Graham, PA, Chassy, LM & Kirkpatrick, JF 2005, 'Immunologic responses and adverse reactions to Freund's-adjuvanted porcine zona pellucida immunocontraceptives in domestic cats', Vaccine, vol. 23, no. 48-49, pp. 5646-5654. https://doi.org/10.1016/j.vaccine.2005.05.044
Munson, L. ; Harrenstien, L. A. ; Acton, A. E. ; Graham, P. A. ; Chassy, L. M. ; Kirkpatrick, J. F. / Immunologic responses and adverse reactions to Freund's-adjuvanted porcine zona pellucida immunocontraceptives in domestic cats. In: Vaccine. 2005 ; Vol. 23, No. 48-49. pp. 5646-5654.
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