Immunologic response of the bovine fetus to inactivated infectious bovine rhinotracheitis infectious pustular vulvovaginitis virus

J. W. Kendrick, Bennie Osburn

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

7 bovine fetuses ranging in gestational age from 3 to 8 mth were intramuscularly inoculated with an inactivated infectious bovine rhinotracheitis infectious pustular vulvovaginitis (IBR IPV) virus. Between post inoculation (PI) days 30 and 60, the fetuses were removed from the uterus by cesarean section. At this time, the gestational age ranged from 5 to 9 mth. Of the 7 fetuses, 6 fetuses, including 2 that were 5 and 6 mth of gestational age, respectively, had virus neutralizing antibody ranging in titer from 1:2.8 to 1:11. Splenic extract of all fetuses had virus neutralizing antibody ranging in titer from 1:5.6 to 1:11. Fetuses, except the 1 that did not have virus neutralizing antibody in the serum, had increased immunoglobulin G (IgG) concentrations. The lymphoreticular system had evidence of antigenic stimulation.

Original languageEnglish (US)
Pages (from-to)1567-1571
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume34
Issue number12
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • veterinary(all)

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