Immunologic characterization of oligodendroglia

O. Abramsky, R. P. Lisak, David E Pleasure, D. H. Gilden, D. H. Silberberg

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Oligodendrocytes were isolated from bovine white matter by trypsinization and sucrose gradient centrifugation, and were injected into rabbits. Indirect immunofluorescence studies showed that antisera reacted specifically with the surface of isolated oligodendrocytes in suspension, as well as with perineural and interfasicular oligodendroglia in bovine and human brain sections. This activity was blocked by pre-incubation of cells or brain sections with non-fluoresceinated goat anti-rabbit immunoglobulin, and absorbed by oligodendrocytes or white matter, but not by purified myelin, neuroblastoma or liver.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalNeuroscience Letters
Volume8
Issue number4
DOIs
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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