Immunologic characteristics of hereditarily asplenic (Dh/+) New Zealand Black x White F1 mice

M. Eric Gershwin, Kent L Erickson, J. J. Castles, A. Ahmed, R. M. Ikeda

Research output: Contribution to journalArticle

Abstract

The natural history of spontaneous immunopathology and autoimmune phenomena was studied in hereditarily asplenic New Zealand Black x White F1 (NZB/W) hybrid mice. NZB/W mice, independent of sex, and including both Dh/+ and +/+ animals, had major age dependent reductions in immune function, including reduction in responsiveness to mitogens and sheep red blood cells and an inability to be tolerized by bovine gamma globulin. In contrast, there were major differences between male and female Dh/+ and +/+ mice with respect to survival and expression of renal disease. Dh/+ female mice had a lower median survival than +/+ mice; in contrast, male Dh/+ mice live longer than +/+ controls. These alterations in survival were reflected in renal and choroid plexus histology and proteinuria. The differences between female NZB/W Dh/+ and +/+ mice appeared to be accounted for by reductions in serum IgM, but enhanced IgG anti-DNA antibodies. The differences between female NZB/W Dh/+ and +/+ mice appeared secondary to the negligible titers of anti-nucleic acid antibodies in male Dh/+ animals. Hereditary absence of the spleen is significantly different from either neonatal or adult splenectomy, and its study, in parallel with other New Zealand immunologic mutants, suggests the existence of multiple independent developmental defects in the pathogenesis and clinical expression of autoimmune disease.

Original languageEnglish (US)
Pages (from-to)529-540
Number of pages12
JournalDevelopmental and Comparative Immunology
Volume4
Issue numberC
DOIs
StatePublished - 1980

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New Zealand
Kidney
Choroid Plexus
hydroquinone
gamma-Globulins
Antinuclear Antibodies
Splenectomy
Natural History
Mitogens
Proteinuria
Nucleic Acids
Autoimmune Diseases
Immunoglobulin M
Sheep
Histology
Spleen
Immunoglobulin G
Erythrocytes
Antibodies
Serum

ASJC Scopus subject areas

  • Developmental Biology
  • Immunology

Cite this

Immunologic characteristics of hereditarily asplenic (Dh/+) New Zealand Black x White F1 mice. / Gershwin, M. Eric; Erickson, Kent L; Castles, J. J.; Ahmed, A.; Ikeda, R. M.

In: Developmental and Comparative Immunology, Vol. 4, No. C, 1980, p. 529-540.

Research output: Contribution to journalArticle

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