Immunologic and hematopoietic effects of recombinant human prolactin after syngeneic bone marrow transplantation in mice

Rui Sun, Ruth A. Gault, Lisbeth A. Welniak, Zhigang G. Tian, Susan Richards, William J Murphy

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The period of immune deficiency following bone marrow transplantation (BMT) results in a susceptibility to opportunistic infections and remains a growing obstacle in improving the efficacy of BMT. Neuroendocrine hormones have been shown to affect numerous immunologic and hematologic responses after in vivo administration. We investigated whether neuroendocrine hormones, notably prolactin (PRL), could be administered after BMT and result in improved immunologic recovery. Mice were given lethal total body irradiation followed with a congeneic or a syngeneic BMT. Some groups then received recombinant human PRL (rhPRL) daily for 3 weeks. Effects on immune reconstitution and function were then monitored. The results show that PRL could increase thymic cellularity and donor T-cell reconstitution after congeneic BMT. Increases in B cells and myeloid progenitors were also observed. Mitogenic responses by both T and B cells were observed after PRL treatment. These results suggest that PRL may be of use to promote immune and myeloid reconstitution after BMT.

Original languageEnglish (US)
Pages (from-to)426-434
Number of pages9
JournalBiology of Blood and Marrow Transplantation
Volume9
Issue number7
DOIs
StatePublished - Jul 2003
Externally publishedYes

Keywords

  • Bone marrow transplantation
  • Hematopoiesis
  • Immune reconstitution
  • Neuroendocrine hormones
  • Prolactin

ASJC Scopus subject areas

  • Transplantation

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